The goal of this observational study is to assess the impact of the COVID-19 pandemic oncolorectal cancer (CRC) outcomes, particularly focusing on stage distribution andrecurrence-free survival in patients undergoing surgery at eight tertiary careinstitutions in Korea from 2018 to 2020.Main Question Does the COVID-19 pandemic lead to more advanced stages of colorectalcancer at diagnosis and higher complication rates during surgery? Is there a significantdifference in recurrence-free survival between CRC patients treated before and during thepandemic?This study found that more patients presented with advanced-stage CRC during the COVID-19pandemic, with significantly higher rates of tumor-related complications (perforations,abscesses, and preoperative obstructions), as well as an increase in open surgeries andcombined resections.No significant difference in recurrence-free survival was observed between thepre-COVID-19 and COVID-19 periods, although postoperative complication rates were higher,especially among rectal cancer patients and those receiving preoperativechemoradiotherapy.
This observational, population-based, cohort study was conducted in accordance with the
Strengthening the Reporting of Observational Studies in Epidemiology guidelines. It was
approved by the regional ethics committee in the Republic of Korea and institutional
review boards of the eight participating institutions. Due to the anonymity of the data,
the requirement for informed consent was waived.
The study timeline was determined by the phased social distancing measures implemented in
the Republic of Korea in response to the COVID-19 pandemic. The study focused on patients
with CRC who underwent surgical treatment from 2018 to 2020. The pre-COVID-19 period
extended from 2018 to February 2020, and the COVID-19 period began in March 2020 with the
identification of the first COVID-19 case in the Republic of Korea and subsequent
government measures to prevent the spread of the disease.
Eight institutions across the Republic of Korea participated in the study, including Asan
Medical Center, Seoul St. Mary's Hospital, Korea University Anam Hospital, Samsung
Medical Center, Pusan National University Yangsan Hospital, Gangnam Severance Hospital,
Kyungpook National University Chilgok Hospital, and Chonnam National University Hwasun
Hospital. These institutions are tertiary medical centers, varying in location and size.
Inclusion Criteria:
- Patients diagnosed with colorectal cancer who underwent surgery
- in 8 institution including Asan Medical Center, Seoul St. Mary's Hospital, Korea
University Anam Hospital, Samsung Medical Center, Pusan National University Yangsan
Hospital, Gangnam Severance Hospital, Kyungpook National University Chilgok
Hospital, and Chonnam National University Hwasun Hospital
Exclusion Criteria:
- Familial adenomatous polyposis (FAP)
- Hereditary non-polyposis colon cancer (HNPCC)
- Cancer associated with inflammatory bowel disease (IBD)
- Colorectal cancer not proven on biopsy, and pathologies other than adenocarcinoma.
- Emergency operation
Asan medical center
Seoul 1835848, Songpa, South Korea
Not Provided