Although respiratory symptoms were predominant in patients infected with COVID-19,gastrointestinal symptoms were always reported in about 10% patients. Previous studiesdemonstrated that the SARS-CoV-2 virus still persists in stool samples for a long timeafter initial infection. Moreover, some patients had a longer duration ofCOVID-19-related gastrointestinal symptoms, which was defined as "post-acute COVID-19syndrome".Previous studies have shown that functional gastrointestinal disorders may occur afteracute gastroenteritis. Functional dyspepsia (FD) is one of the most common functionalgastrointestinal disorders. FD was reported to be correlated with multiplepathophysiological mechanisms, including GI bacterial imbalance, disordered gutmicrobiota, and disturbed barrier and immune function. It is unknown whether COVID-19infection could exacerbate the symptoms of FD. Therefore, we followed up a group of FDpatients before and after COVID-19 and investigate the impact of COVID-19 infection onthe symptoms of FD.