1. Background and Overview Aditxt, Inc, in collaboration with researchers at Stanford
University, has laboratory-developed tests (LDTs) for simultaneously monitoring
anti-SARS-COV2 antibodies (IgG, IgA, and IgM) directed against 3 different
SARS-CoV-2 antigens (RBD, S1, and NP) as well as assessing SARS-CoV-2 neutralizing
antibody activity.

These tests are currently being offered routinely to the public as the AditxtScoreTM
at Aditxt's CLIA certified, CAP accredited clinical laboratory in Richmond, VA.
Aditxt also performs these tests for research and development purposes at a facility
in Mountain View, CA. The AditxtScore provides an ideal platform for real- world
investigations of immune responses to SARS-CoV-2 exposure as well as to the COVID-19
vaccines.

The overall purpose of this observational cohort study is to characterize
COVID-specific immune responses to SARS-CoV-2 exposure or COVID vaccination in a
real-world setting. Participants will be asked to provide blood samples (either a
normal venous blood draw, a few drops of blood obtained with a small finger-stick
device, or both), as well as saliva or nasal swab sample at a series of visits.
Subjects will receive results of the testing that is approved for routine clinical
use (i.e., their AditxtScore), while residual samples from each visit will be stored
for future testing. These efforts will support ongoing AditxtScore test development
and enhance the effectiveness of its interpretation - aiding efforts to maximize
benefits of clinical laboratory testing in the pandemic response.

2. Objectives • To characterize immune responses (e.g., magnitude/strength and temporal
dynamics of antibody generation, class switching, and antibody persistence)
following exposure to the SARS-CoV-2 virus or COVID-19 vaccination.

• To investigate between group (eg vaccine vs. natural exposure) and within group
(i.e., individual variation) differences in immune responses.

• To determine the relationship between AditxtScore components and neutralizing
antibody activity and other potential correlates of protection, and to describe
possible clinical correlates of immune response characteristics.

• To support test development activities such as determining appropriate clinical
cutpoints, analyte stability, and comparability of results from different sample
types (e.g., venous blood draw vs fingerstick blood drop, nasal swab vs. saliva
collection). These activities will support refinement of existing tests as well as
development of future tests (e.g. COVID-19 specific memory B cell, T cell, and NK
cell responses).

3. Study Procedures 3a. Subject Recruitment Subject recruitment will consist primarily
of word-of-mouth efforts of study personnel (e.g. friend and family networks) and
other interested parties in the local community (e.g. a handful of local
physicians). No broad advertising campaign is anticipated, though a study
announcement flyer describing the study opportunity will be used to support
recruitment efforts. Potential subjects will be directed to call Aditxt to schedule
a time to come to the laboratory and learn more about the study.

Anyone with a prior history of SARS-CoV-2 exposure, a possible current infection, or a
vaccination history is eligible to participate, in addition to negative controls when
needed. Efforts will be made to include a representative mix of ages, genders, and
ethnicities.

In the special circumstance that a potential subject would like to participate in the
study but is unable to come to either Aditxt location (in Richmond, VA or Mountain View,
CA) and has access to a qualified phlebotomist, collection materials can be shipped to a
qualified phlebotomist in their area for collections. In this case samples would be
shipped overnight to Aditxt for processing. The consent forms and patient questionnaire
will be emailed to the participant ahead of time and reviewed with the investigator
remotely (e.g., via zoom or phone call), signed, and submitted to Aditxt along with the
samples.

3b. Administration of Informed Consent and Protection of Privacy Potential study
participants will be taken to a private room at Aditxt's facility in either Richmond, VA
or Mountain View, CA and the consent form will be explained to them by a member of the
study team. Once all questions are answered, if they choose to participate they will sign
the consent form. In a situation where the samples are being collected at a different
location, the consent and authorization forms will be emailed to the potential subject,
printed, and reviewed with a member of the study team remotely (e.g. via zoom or phone
call) until all questions have been answered. The consent documents will then be signed
and submitted along with the sample.

Study personnel will then assign the participant a subject number and enter the subjects
name, subject number, and date of consent on an electronic enrollment log (in an Excel
spreadsheet). The enrollment log will be maintained in a secured location on Aditxt's
file server with access restricted only to designated study personnel.

The subjects name and date of birth will be used when performing the "routine" testing at
each visit (i.e., the PCR virus test and the antibody tests), and standard clinical
reports with their names - appropriate for talking to their regular physicians - will be
generated and delivered to the subjects. However, only the subject numbers will be used
to identify the patient questionnaires and the sample aliquots stored for future testing.

4c. Completion of Patient Questionnaire Once enrolled, subjects will be provided a brief
questionnaire to complete to capture information about demographics, any symptoms that
may be related to COVID, any comorbid conditions, and current medications they are
taking. A followup questionnaire will be provided at each follow-up visit.

4d. Sample Collection

- Health and Safety Precautions Due to the potential risk of viral transmission, the
following safety precautions will be adhered to for every study collection (these
are the same precautions required by Aditxt for all routine sample collections)

- Only one subject will be allowed in the collection area at a time.

- Proper Personal Protective Equipment (PPE) must always be worn by collection
personnel when within 6 feet of the patient. This includes a protective gown,
gloves, protective mask and face shield.

- Patients must wear a protective mask in the collection area except when
temperature measurement and nasal swab collection are performed.

- Laboratory collection personnel will clean the collection seat with a
disinfectant wipe between patient collections.

- After collection and the patient has left the collection area, laboratory
collection personnel will change gloves and use hand sanitizer at multiple
steps in the removal of PPE as outlined in the Procedure section below to
ensure no contamination of touched surfaces, including the protective gown,
face shield and protective mask.

- After removal of PPE, laboratory collection personnel will wash hands with soap
and water before starting the next patient collection.

- Face shields will be cleaned with a disinfectant wipe between every patient
collection.

- Protective masks and gowns may be stored for reuse between patient collections
if no contamination of the PPE is observed or suspected.

- Phlebotomy Blood samples will be collected identically to those routinely collected
for clinical practice, as described in Aditxt's SOP 6037 Anti-SARS-CoV-2 Phlebotomy
Procedure.

- Saliva Participants will be asked to rinse their mouth with water 5 minutes prior to
collection. They will be provided with a 3mL tube and asked to fill it (by allowing
saliva to pool in their mouths and then spitting it into the tube).

- Nasal Swabs Nasal swab samples will be collected identically to those routinely
collected for clinical practice, as described in Aditxt's SOP 6036 SARS-CoV-2 Nasal
Swab Collection Procedure.

- Finger-stick

Fingerstick capillary blood collection will be performed as follows:

- Wipe the puncture site (the tip of whichever finger the subject prefers) with an
alcohol pad and remove the protective cover from the lancet.

- Position the lancet perpendicularly to the underside of the finger and puncture the
skin by gently pressing the lancet against the puncture site until it activates.

- Gently apply pressure to the surrounding tissue. Discard the first drop of blood.

- Hold the finger and capillary tube in a downward position. Touch the tip of the
capillary to the blood droplet. The tube will fill automatically due to the
capillary effect. Collect 3-4 drops of blood (150-250 microL).

- After blood collection, remove the capillary from the tube, dispose of and apply
pressure to the puncture site.

- After collection, invert the tube gently several times.

- Apply band-aid to the puncture site.

4e. Follow-up Visits Subjects will be encourage to return to Aditxt every 1-2 months
for additional sample collection for up to 2 years. An updated questionnaire will be
completed by the subject at each follow-up visit. Questionnaire and laboratory data
will be stored in the study database and identified only by subject number, allowing
for additional studies to be performed on the now deidentified data.

4f. Laboratory Procedures / Reporting The anti-SARS-CoV-2 antibodies and
neutralizing antibody activity will be assessed by the AditxtScoreTM flow cytometry
method from Aditx Therapeutics. Antigen/virus testing will be performed on the iAMP
COVID-19 system from Atila Biosystems. Clinical laboratory reports describing
results of this testing will be provided to subjects (exactly as if they had
purchased the testing directly).

Additionally, reporting requirements laid out by the US Department of HHS and the
Virginia Department of Health will be complied with. Our approach to reporting all
routine results is consistent with FDA guidance (Policy for Coronavirus Disease-2019
Tests During the Public Health Emergency (Revised)). Results of future experimental
testing performed on stored samples will be de-identified. Individuals will not be
notified of future experimental test results.

AditxtScoreTM

o Novel flow cytometry-based method that allows for simultaneous monitoring of IgG, IgA,
and IgM antibodies against 3 different COVID antigens, accompanied with a test for
corresponding neutralizing antibody activity

iAMP COVID-19 system (Atila Biosystems)

- Isothermal amplification PCR technology detecting sequences from both the "N" gene
and the ORF-1ab gene of the SARS-CoV-2 virus

- Approved for use by the FDA under an EUA Aditxt is currently offering this test
service routinely).