The goal of this observational study is to measure the changes in the parameters ofendocrine function and tissue sensitivity to hormones induced by SARs-CoV-2 infection.The main questions it aims to answer are: - Does SARs-CoV-2 infection causes endocrine dysfunctions? - Does the treatment of the underlying endocrine dysfunctions, improves the clinical outcome or the occurrence of late onset complications of SARs-CoV-2 infection? - Are patients with previously known endocrine diseases more fragile in case of SARs-CoV-2 infection? Participants will undergo blood testing and a physical examination at admission, during hospitalization at discharge and 3 and 6 moths after discharge They results will be compared to those of patients admitted for other reasons in order to assess whether the prevalence of endocrine dysfunctions is increased compared with controls.
The objectives of the study are the following:
Primary objectives:
1. to measure endocrine function tests in patients affected by COVID-19, in order to
evaluate whether SARs-CoV-2 causes endocrine alterations and whether endocrine
diseases/dysfunctions correlate with the severity of SARs-CoV-2 infection and
mortality.
2. to evaluate whether genetic variants in the sex-steroid or vitamin D (VDR) nuclear
receptors or ACE are more prevalent in patients with SARs-CoV-2 infection than
controls.
3. to evaluate whether vitamin D supplementation in subjects with vitamin D deficiency
may influence the outcome of SARs-CoV-2 infection
4. To correlate the influence of overweight/obesity/neck circumference with the
evolution of SARs-CoV-2 infection
Secondary objectives:
Correlate the endocrine function tests with patients' age, disease's outcome, markers of
inflammation.
The identification of endocrine conditions associated with a worse outcome of SARs-CoV-2
infection, would identify significant risk factors to be reduced/prevented in these
patients. For example, if endocrine patients will result more fragile in case of
infection, we could systematically screen some parameters and early treat associated
defects in order improve the outcome of SARs-CoV-2 infection.
Other: blood testing
blood testing for basal hormones and markers of inflammation
Other Name: thyroid US scan in case of thyroid dysfunctions
Inclusion Criteria:
- Nasal swab positive for Sars-CoV-2
- Moderate to severe respiratory dysfunction due to COVID-19, requiring
hospitalization.
Exclusion Criteria:
- History of thyroid diseases before admission
- History of adrenal diseases
- History of hypogonadism (primary/secondary)
- History of pituitary diseases
Istituto Auxologico Italiano IRCCS
Milan, Italy
Luca Persani, MD, PhD, Principal Investigator
Istituto Auxologico Italiano IRCCS