To evaluate the effectiveness of Nigella Sativa and honey stirred in 250 ml of distilled water 12 hourly till patient becomes asymptomatic or a maximum of 14 days with standard hospital care versus standard hospital care alone with placebo capsule and 250 ml water, in clearing the COVID-19 nucleic acid from throat and nasal swab, lowering disease detrimental effects on HRCT chest/X-ray and severity of symptoms along with duration of hospital stay till day 14th day of follow up and 30 days mortality (primary outcomes).
This cohort, adaptive, randomized, double armed group, controlled, Investigator Initiated
interventional study is designed to demonstrate the superiority of a combination of black
cumin with honey over standard care in SARS-CoV-2 (COVID-19) infected patients who consent to
randomization following a new diagnosis in Pakistan with an SSC-2 score of > 5 with positive
RT-PCR of COVID-19.
Drug: Honey
1gm/Kg/Day
Drug: Nigella Sativa / Black Cumin
80mg/Kg/day
Drug: Placebos
Empty capsule with 250ml of distilled water
Inclusion Criteria:
- Confirmed SARS-CoV-2 (COVID-19) infection by a positive test result with SSC-2 score>
5
- Patients admitted in Corona centers
Exclusion Criteria:
- Participants not giving consent.
- Pregnant and lactating females.
- History of allergy to any drug being administered in this study
- Severely terminally ill patients
- Patients on Nil Per Oral
Federal Post-Graduate Medical Institute, Shaikh Zayed Hospital
Lahore, Punjab, Pakistan
Services Institute of Medical Sciences, Services Hospital
Lahore, Punjab, Pakistan