The aim of the study is to study the genotypic characteristics of HIV-1 non-M circulatingin the whole Cameroon and their genetic evolution.
HIV-1 is divided four distinct groups: M (major) which represents the pandemic strains
while others groups O (outlier), N (non M, non O) and P are called non-M variants. Group
O (HIV-O) is more divergent, endemic in Central Africa and Cameroon, where it represents
about 1% of HIV infections. These variants are characterized by an important genetic
divergence from pandemic HIV-1 group M (HIV-M), which impacts on the diagnosis,
monitoring and treatment of infected patients. Although discovered in 1990, and emerged
at the same time as HIV-M, no data of epidemiology, natural history and evolution of the
genetic diversity of these variants is currently available. The few knowledge available
to date come from sporadic cases, mainly through studies in Yaoundé. It is therefore
essential to improve current knowledge on these variants and their consequences on
infected patients.
The aim of the study is to study the genotypic characteristics of HIV-1 non-M circulating
in the whole Cameroon and their genetic evolution.
Diagnostic Test: Prospective
Blood samples will be collected in order to meet the objectives of this substudy and
possibly for complementary research
Inclusion Criteria:
- All available samples tested positive for HIV during the national Health survey of
Cameroon in 2011 And 2018
- All Individuals who came to Centre Pasteur in Yaoundé or Garoua for HIV screening or
viral load monitoring.
Exclusion Criteria:
- Insufficient quantity or degraded Dried Blood Spot samples
- All HIV-positive individuals aged less than 21 years, infected with a Group M HIV-1
virus, or those who refused to participate in the study
Not Provided
Mariam Gharib, PhD
0144236442
mariam.gharib@inserm.fr
Elodie Alessandri-Gradt, ParmD PhD
+33232855885
elodie.alessandri@chu-rouen.fr
Not Provided