Official Title
High-Definition Transcranial Direct Current Stimulation (Hd-Tdcs) and Chlorella Pyrenoidosa as an Adjuvant Treatment to Reduce Cardiovascular Risk in Patients With Long COVID
Brief Summary

Recent investigations have shown that of the patients who were affected by SARCov2 haveremained with persistent symptoms in a high proportion. In these considerations, theliterature has suggested nomenclatures such as "post-COVID-19" and "chronic COVID-19","long -COVID" and Post-Covid Syndrome for patients recovered from SARCov2 reportingpersistent symptoms and signs for weeks to months after resolution of the acuteinfection. Furthermore, there may be cardiovascular complications in affected patients,the consequences of which can lead to muscle contractility disorders, vascularinsufficiency, cardiac arrest, reinforcing the need for controlled, randomized studies,as well as follow-up and monitoring of these. Furthermore, cardiovascular diseases (CVD)are part of the health problems that lead to the most deaths in the world, they also leadto a high proportion of hospital admissions, due to the worsening of the pathology and ahigher incidence in the elderly population. The worsening of CVD conditions leads toinadequate food consumption at the hospital level, causing changes in several nutrients,including vitamin B12. The reduction in B12 levels leads to changes in several systems,including the cardiovascular system, and due to the increase in homocysteine and thetriggering of the inflammatory cascade. Studies indicate that B12 supplementation throughChlorella (microalgae - functional food) reduced cardiovascular risk and modulated theinflammatory cascade. In combination, neurostimulation has presented aspects that promotepain neuromodulation, due to the improvement of respiratory patterns and inflammatorymodulation. More specifically, there is a protocol with promoting findings, this beingHD-tDCS. In this sense, this research aims to evaluate the effects of HD-tDCS and theconsumption of Chlorella Pyrenoidosa to improve B12 levels in patients withcardiovascular risk post-COVID-19.

Detailed Description

This study is an open label research, clinical trial, double blind, placebo controlled,
and randomized, involving assistance to patients at risk of cardiovascular disease, in
outpatient care (Continue Caring Project). Included in the research are adults and
elderly participants at cardiovascular risk, whose initial diagnosis for hospitalization
was due to COVID-19 and at the hospital level those admitted for treatment in the
Intensive Care Unit or ward with heart disease who are eligible for neurostimulation by
HD-tDCS. Patients will be randomly allocated into an experimental and control group for
HD-tDCS and also to receive the functional food. The protocol will be HD-tDCS (lasting 20
minutes of 4x1 tDCS-HD) positioning the central electrode in the left primary motor
cortex (M1) with anodal stimulus, twice a week; nutritional monitoring; collection of
laboratory tests (at the beginning and end of treatment) and the group that will receive
the functional food will be provided with 10 tablets of Chlorella Pyrenoidosa (5g/day)
containing 4mcg of B12, organic pressed into tablets (Registration with ANVISA/MS :
6,7273,000) for five weeks.

Recruiting
Cardiovascular Diseases
Long Covid19

Other: High Definition-transcranial Direct Current Stimulation

High-Definition transcranial Direct Current Stimulation (HD-tDCS) is a neuromodulation
technique, is non-invasive, targeted, safety.

Dietary Supplement: Chlorella Pyrenoidosa

functional food, organically pressed into tablets (Registration with ANVISA/MS:
6.7273.000)

Eligibility Criteria

Inclusion Criteria:

- Patients with cardiovascular diagnosis or risk;

- Adults and elderly people (18 to 80 years old);

- Able to respond to commands and grant consent to participate in the research through
the informed consent form;

- Who have post-COVID symptoms.

Exclusion Criteria:

- Patients with a clinical history of neuromuscular or cognitive instability,
pregnancy and contraindications for receiving neurostimulation (such as cardiac
pacemakers and metallic brain implants);

- Patients with contraindications to the use of Chlorella (gastritis, esophagitis,
peptic ulcers),

- Pregnant patients, patients with stroke and tumors

Eligibility Gender
All
Eligibility Age
Minimum: 20 Years ~ Maximum: 80 Years
Countries
Brazil
Locations

Vanessa Meira Cintra
João Pessoa, Paraíba, Brazil

Investigator: Suellen Andrade, Phd
Contact: (83) 986046032
suellenandrade@gmail.com

Contacts

Suellen Andrade, PhD
+55(83)986046032 - 5833
suellenandrade@gmail.com

Vanessa Meira Cintra, Msc
+55(83)999966528 - 5511
vanessameiracintra@gmail.com

Not Provided

City University of New York
NCT Number
MeSH Terms
Post-Acute COVID-19 Syndrome
Cardiovascular Diseases