For tumor patients, the virus antibody titer produced by the SARS-CoV-2 vaccine is oftenlower than that of normal people in a short period of time, but in the long run, it cansignificantly reduce the infection rate and fatality rate of the new coronavirus, and theadverse reactions are mild and there is no significant difference with normal people.However, there is still no real-world research data in China to prove the protectiveeffect of the SARS-CoV-2 vaccine on patients with tumors infected with the SARS-CoV-2virus.
To explore the protective effect of SARS-CoV-2 vaccination on cancer patients infected
with SARS-CoV-2. Serum samples were collected from cancer patients who had been infected
with SARS-CoV-2 and were previously vaccinated or unvaccinated. The SARS-CoV-2 antibodies
(IgG and IgM concentrations) were detected by micro-magnetic particle chemiluminescence
method, and the differences were compared. The results of this real-world prospective
cohort study can be used to guide the vaccination of cancer patients in clinical
practice.
Other: no intervention
no intervention
Inclusion Criteria:
1. age > 18 years old, regardless of gender;
2. patients with previous or current tumor, regardless of tumor type;
3. have a history or current infection with SARS-CoV-2;
4. The vital signs were stable, without severe pulmonary, heart, liver and other
important organ dysfunction;
5. those with good compliance, agreed to participate in this clinical study, receive
corresponding treatment, and signed the informed consent.
Exclusion Criteria:
1. Those who do not meet the inclusion criteria or diagnostic criteria, and cannot
cooperate with blood sampling and arrangement;
2. patients with severe bleeding disorders such as coagulopathy or essential
thrombocytopenia;
3. local skin ulceration affecting blood drawing, severe rash, or infectious diseases;
Sanhuan Cancer Hospital, Chaoyang District, Beijing(Cancer Hospital, Chinese Academy of Medical Sciences, close medical alliance)
Beijing, Beijing, China
Investigator: zhang yu rong
Contact: 010-67487559
shzlyyllwyh@163.com
yang zi xuan
18801349043
2573100063@qq.com
yuan peng, M.D., Principal Investigator
Cancer Institute and Hospital, Chinese Academy of Medical Sciences