Official Title
An Clinic Trial of Recombinant Human Interferon Alpha Nasal Drops to Prevent Coronavirus Disease 2019 in Medical Staff in Epidemic Area
Brief Summary

The investigators plan to carry out an experimental study on the preventive effect of recombinant human interferon alpha nasal drops on the infection of 2019 new coronavirus in medical staff.

Detailed Description

The investigators plan to carry out an experimental study enrolling more than 2000 medical
staff and divide participants into low-risk group and high-risk group according to whether
they can directly exposed to 2019-nCOV infected patients. In the low-risk group, participants
will be given recombinant human interferon alpha-1b nasal drops (2-3 drops/nostril/ time, 4
times/ day), and in the high-risk group will be given preventive intervention with interferon
nasal drops and thymosin-α (thymosin was injected subcutaneously once / week), and the
intervention time is 28 days.

Unknown status
2019 Novel Coronavirus Infection

Drug: recombinant human interferon Alpha-1b

recombinant human interferon Alpha-1b nasal drops, 2-3 drops for each nostril per time, 4 times per day.
Other Name: interferon α

Drug: thymosin alpha 1

thymosin alpha 1 subcutaneous injection 1 time per week.
Other Name: thymosin α

Eligibility Criteria

Inclusion Criteria:

- Formally serving medical staff in Taihe Hospital;

Exclusion Criteria:

- pregnant women;

- severe chronic diseases who are unable to participate in daily routine work;

- fever (temperature≥37.3 ° ) and / or respiratory symptoms.

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: 65 Years
Countries
China
Locations

Taihe Hospital
Shiyan, Hubei, China

Investigator: Zhongji Meng
Contact: +86-18971905757
zhongji.meng@163.com

Contacts

Zhongji Meng
18971905757
zhongji.meng@163.com

Shanghai Jiao Tong University School of Medicine
NCT Number
Keywords
rhINF-α
2019-nCOV
prophylaxis
MeSH Terms
Coronavirus Infections
COVID-19
Interferons
Interferon-alpha
Interferon-alfa-1b
Thymalfasin