Inclusion Criteria:

1. Capable of giving signed informed consent which includes compliance with the
requirements and restrictions listed in the informed consent form (ICF) and in this
protocol

2. Participant must be able to comply with study procedures and be available for all
study visits.

3. Previously receive COVID-19 vaccines either homologous or heterologous vaccination
at least 3 doses and the last booster dose for more than 6 months prior to Visit 2
(Day 1).

4. Be aged between 18 and 64 years, inclusive, at the time of signing informed consent

5. Have a BMI between 18.5 and 35.0 kg/m2 inclusive

6. Healthy as determined by the Investigator based on pre-study medical history,
physical examination and vital signs

7. Males must be surgically sterile (> 30 days since vasectomy with no viable sperm),
practice true abstinence, or, if engaged in sexual activities with a female with
childbearing potential, use condoms from the time of vaccination until 60 days after
the vaccination

8. Females of childbearing potential must practice true abstinence, or, if engaged in
sexual activities with a male, agree to use highly effective (failure rate of <1%
per year when used consistently and correctly), double-barrier contraceptive
measures* for at least 60 days following vaccination.

- PI to assess the suitability of contraceptive measures on a case-by-case basis.
The measures can include: combined (estrogen and progestogen) hormonal
contraception associated with inhibition of ovulation, progestogen-only
hormonal contraception associated with inhibition of ovulation, intrauterine
device, intrauterine hormone releasing system, and documented bilateral tubal
occlusion hysterectomy, bilateral salpingectomy, bilateral Essure® placement,
and bilateral ovariectomy.

Exclusion Criteria:

1. Known history of COVID-19 infection within 6 months at screening or Visit 2 (Day 1).

Participants who screen-fail on this criterion may be rescreened.

2. Have received any investigational COVID-19 vaccine.

3. Have received any other vaccine within 30 days prior to Visit 2 (Day 1) or plan to
receive any other vaccine within 30 days after Visit 2 (Day 1) as per the
investigator's judgment. Participants who screen-fail on this criterion may be
rescreened.

4. Have an ongoing AE assessed as related to any prior COVID-19 vaccine or COVID-19
disease as per the investigator's judgment.

5. Women who are pregnant, breast feeding or planning to become pregnant within 60 days
of vaccination and men who plan to conceive a child within 60 days of vaccination.

6. Has a clinically unstable chronic underlying disease such as hypertension, diabetes
mellitus, chronic obstructive pulmonary disease, asthma, or any other condition for
which, in the opinion of the investigator, participation would not be in the best
interest of the participant or that could prevent, confound, or limit the
assessments specified in the protocol.

Except for stable symptoms and signs that are medically controlled in the judgment
of the investigator, which can be enrolled.

7. Anticipating the need for immunosuppressive treatment within the 6 months following
Visit 2 (Day 1).

8. Being treated with other registered or investigational drug for prophylaxis or
treatment of COVID-19 such as EVUSHELD or receive within 6 months prior to
vaccination or plan to receive within 6 months after vaccination.

9. Immunosuppressive illness or immunodeficient state, including hematologic
malignancy, history of solid organ or bone marrow transplantation, asplenia, primary
immunodeficiency diseases and HIV infection.

10. Cancer or any malignancy that has been in remission for less than 5 years, except
for basal cell or squamous epithelial carcinomas of the skin that have been resected
with no evidence of metastatic disease for 3 years.

11. Administration of other investigational products, or blood products within 4 weeks
prior to Visit 2 (Day 1) or planned administration of investigational products,
blood products, blood or tissue donation, or blood transfusion within 6 months after
Visit 2 (Day 1).

12. Clinically significant abnormalities in clinical laboratory tests during Screening
in the opinion of the Investigator.

13. Presence of self-reported or medically documented significant medical or psychiatric
condition(s) that as judged by the investigator(s) may not be in the participants'
interest to participate in the study.

14. History of severe allergy (requiring hospital care), anaphylaxis, severe reaction to
any drug or prior vaccination, or any known or suspected allergies or sensitivities
to any component of the investigational vaccine or tobacco.

15. History of systemic steroids (prednisone ≥ 20 mg/day for >14 consecutive days)
within 3 months prior to screening. Topical, inhaled, intranasal, and
intra-articular corticosteroids are allowed regardless of dose.

16. Receipt of immunoglobulins or blood products within 90 days prior to vaccination or
planned treatment during the study periods.

17. Thrombocytopenia or other coagulation disorders for whom IM injections are
contraindicated or receiving anticoagulant therapy.*

* Anticoagulant therapy: continuous use of anticoagulants such as coumarin/warfarin
or new oral anticoagulants/antiplatelets. The use of aspirin or clopidogrel is
acceptable.

18. Alcoholism, history of alcohol or drug abuse that, in the opinion of the PI, could
affect the participant's safety or compliance with study, or chronic liver disease
such as cirrhosis at screening.

19. Have received any investigational drug from 30 days prior to Screening until 30 days
after receiving the assigned vaccination in this study.

20. The Investigator, sub-Investigator, study staff, sponsor, pharmaceutical product
development or their family members.

21. Presence of tattoo, bruising, or other skin blemish at the administration site that
would, in the opinion of the Investigator, inhibit the ability to perform an
assessment of local tolerability.

22. Positive HBsAg, anti-HCV or anti-HIV tests at Screening

23. Active COVID-19 infection or COVID-19 positive based on ATK testing at screening or
Visit 2 (Day 1).

24. Presence of an acute illness, as determined by the Investigator(s), with or without
fever (forehead temperature measured with validated device ≥ 37.5oC) within 72 hours
prior to vaccination. Participants who screen-fail on this criterion may be
rescreened following a suitable recovery period as determined by the
Investigator(s).

25. Receipt of herbal medicine (such as products of Andrographis paniculata) within 5
days prior to vaccine administration or within 6 months after vaccination.

26. Any other reason which, in the opinion of the Investigator, makes the individual
ineligible for the study.