Official Title
Evaluation of the Safety and Efficacy of Azvudine and Paxlovid in the Treatment of Hospitalized Patients With COVID-19
Brief Summary

In this retrospective study, we aimed to evaluate the clinical efficacy and safety of twoantiviral drugs on COVID-19 and inpatients with existing complications in the FirstAffiliated Hospital of Shandong First Medical University. In addition, we also explored akey issue. Is the combined treatment effect of two antiviral drugs, Paxlovid andAzvudine, better than the use of a single drug?

Detailed Description

We conducted a single center retrospective cohort study on hospitalized patients with
severe acute respiratory syndrome coronavirus type 2 infection who received treatment
with nimatevir/ritonavir tablets or azivudine tablets at the First Affiliated Hospital of
Shandong First Medical University from December 1,2022 to January 31,2023. In the
research of this project, it is necessary to extract, sort out and retrospectively
analyze the clinical data of all patients with COVID-19 who have received
Nematovir/Ritonavir tablets or Azivudine tablets in the First Affiliated Hospital of
Shandong First Medical University (Shandong Qianfoshan Hospital), and respectively
identify the relevant epidemiological characteristics of COVID-19 patients, It is planned
to use multiple linear regression or logical regression model to explore the relevant
factors that affect the drug use efficiency index, safety index and total cost of
patients with COVID-19, so as to provide scientific and quantitative evidence support for
the drug use mode of the disease, the clinical value of the drug and the rational drug
use of patients, and also provide favorable basis for the supervision and decision-making
of smart pharmacy of medical institutions.

Not yet recruiting
Paxlovid
Azvudine
COVID-19
Eligibility Criteria

Inclusion Criteria:

-

1. The patient's admission time is from December 1,2022 to January 31,2023. 2. The
patient has used either Paxlovid or azivudine tablets during admission. 3. Age
≥ 18 years old. Exclusion Criteria:

-

1. Patients using other antiviral drugs. 2. Patients with incomplete clinical
data.

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Locations

Not Provided

Contacts

Xiao Li
18210590697
lixiao1688@163.com

Not Provided

NCT Number
Keywords
Paxlovid
Azvudine
Covid-19
Effectiveness
Real-world evidence
MeSH Terms
COVID-19