It is planned to include 200 patients hospitalized with primary myocardial infarctionwith and without ST segment elevation (STEMI or NSTEMI) in combination with COVID-19within the first 15 days from the disease onset. The total follow-up period is 96 weeks.Hypotheses: 1. An integrated approach in assessing myocardial contractility, regulation of the heart and the structural and functional state of arteries will make it possible to more accurately assess the heart pumping function; explain the mechanisms of the relationship between left ventricular (LV) contractile function and its volumetric indices; to study the mechanisms of ventriculo-arterial coupling and the influence of autonomic regulation, the role of markers of the sudden cardiac death (late ventricular potentials, pathological turbulence of the heart rate, dispersion of the QT interval). 2. In patients who have had myocardial infarction in combination with the new coronavirus infection SARS-CoV-2 (COVID-19), long-term highly effective lipid-lowering therapy, regardless of the drugs prescribed, has an antiarrhythmic effect and has a beneficial effect on the autonomic regulation of the heart rate. Highly effective lipid-lowering therapy leads to an improvement in LV contractility and structural and functional properties of the large arteries.Methods and variables 1. Office blood pressure 2. 12-lead ECG 3. Coronary angiography. Percutaneous coronary intervention 4. Chemistry blood test 5. 2D and 3D transthoracic echocardiography (Vivid GE 95 Healthcare (USA) 6. Multi-day 3-lead ECG monitoring with assessment of the parameters of myocardial electrical instability. 7. Ultrasound of common carotid arteries using high-frequency radio-frequency signal technology 8. Applanation tonometry (SphygmoCor, AtCor, Australia) 9. Assessment of the arterial stiffness by volume sphygmography. 10. Flow-mediated vasodilation 11. Six-minute walk test 12. Computer pulse oximetry (PulseOx 7500 (SPO medical, Israel) 13. Adherence to Treatment: Counting remaining pills and completing the Morisky-Green Questionnaire 14. Assessment of quality of life 15. Assessment of physical activity: International Questionnaire On Physical Activity - IPAQ 16. Hospital Anxiety and Depression Scale (HADS)
It is planned to include 200 patients hospitalized in the cardiology department of the
"Penza Regional Clinical hospital Burdenko" with a STEMI diagnosis in combination with
COVID-19. Patients with STEMI and NSTEMI will be included in the study within the first
15 days from the disease onset. The total follow-up period is 96 weeks.
Primary goals:
- achieving the target level of low-density lipoprotein cholesterol (LDL-C) on the
background of lipid-lowering therapy as monotherapy with atorvastatin or combined
treatment with atorvastatin plus ezetimibe;
- decrease in the incidence of major coronary events - percutaneous coronary
interventions (PCI) / coronary artery bypass surgery (CABG) for a new case of
coronary atherosclerosis, hospitalization for unstable angina or recurrent
myocardial infarction;
- reduction of the frequency of life-threatening arrhythmias and markers of the risk
of sudden cardiac death according to the data of long-term ECG monitoring;
- increase in myocardial contractility by improving the deformation characteristics of
the peri-infarction zone.
Secondary goals:
1. Assess the effect of long-term effective lipid-lowering therapy:
- indicators of global and regional myocardial deformation, depending on the
degree of of coronary blood flow restoration according to TIMI scale;
- systolic and diastolic LV function in the presence of initial disturbances or
the absence of negative dynamics of these indicators with normal initial
values;
- on clinical and diagnostic criteria for the development or progression of heart
failure (HF);
- on the dynamics of myocardial ischemia episodes according to the data of
long-term electrocardiography (ECG) monitoring;
- for the immediate and long-term prognosis of patients;
- on the structural and functional properties of large arteries.
2. Assess the dynamics of biochemical parameters against the background of double and
monotherapy with lipid-lowering drugs.
3. Assess the safety of treatment.
4. Assess the impact on the patient's well-being and quality of life.
5. Assess therapy compliance
6. Conduct a comparative analysis of the prognostic value of markers of myocardial
electrical heterogeneity, obtained from the data of long-term and 24-hour ECG
monitoring.
7. To determine the effect of markers of electrical instability and autonomic
regulation of cardiac activity, obtained during long-term ECG monitoring in patients
at different times after myocardial infarction, on the short-term and long-term
prognosis.
8. Development of a multivariate model that takes into account the parameters of
electrophysiological heterogeneity and the main indicators of the cardiovascular
system condition (data of echocardiography, blood vessels ultrasound, laboratory
test), which allows predicting the development of repeated cardiac events.
Methods and variables
1. Office blood pressure
2. 12-lead ECG
3. Coronary angiography. Percutaneous coronary intervention
4. Chemistry blood test The lipid profile: total cholesterol (TC), high-density
lipoprotein cholesterol (HDL-C), triglycerides (TG) and low-density lipoprotein
cholesterol (LDL-C), non-HDL. Alanine aminotransferase (ALT), aspartat
aminotransferase (AST), creatine phosphokinase (CPK), glucose, C-reactive protein
(CRP), brain natriuretic peptide (BNP), serum creatinine and glomerular filtration
rate (CKD-EPI), troponin I/T, CPK-MB, ferritin, sodium, potassium, lactate,
procalcitonin, D-dimer, coagulogram. Nasopharyngeal swab for SARS-CoV-2 to RNA by
PCR, if necessary - additional determination of immunoglobulins to SARS-CoV-2.
5. 2D and 3D transthoracic echocardiography is performed with Vivid GE 95 Healthcare
(USA). The biplane ejection fraction is determined by the Simpson method, 3D
ejection fraction, EDV (end-diastolic volume), ESV (end-systolic volume) and their
indexed parameters in 2D and 3D mode. Left ventricular myocardial mass index (LVMI),
LA volume. Myocardial deformity is analyzed using specialized software - EchoPac
Software Only (General Electric Co., 2018)
6. Multi-day 3-lead ECG monitoring with assessment of the parameters of myocardial
electrical instability.
7. Ultrasound of common carotid arteries using high-frequency RF signal technology will
be carried out in B-mode on the MyLab 90 device (Esaote, Italy) by the following
indicators: IMT - thickness of the intima-media, loc Psys - local systolic pressure
in the carotid artery, loc Pdia - local diastolic pressure, P (T1) - pressure at a
local point, stiffness indices β and α, DC - coefficient transverse distensibility,
CC - transverse compliance coefficient, Aix - augmentation index, AR - amplification
pressure, PWV - local pulse wave velocity in the carotid artery.
8. Applanation tonometry The SphygmoCor device (AtCor Medical, Australia) includes two
software. The first allows to record indicators of central aortic pressure: systolic
aortic pressure - SBPao, diastolic - DBPao, pulse pressure - PPao, mean hemodynamic
pressure - MBPao. The PWV (pulse wave velocity) software is used to analyze the PWV
in the aorta (cfPWV).
9. Assessment of the arterial stiffness by volume sphygmography. PWV in the aorta
(PWV), in elastic arteries right and left (R/L-PWV) and in muscular arteries
(B-PWV), Cardio-Ankle Vascular Index - CAVI.
10. Flow-mediated vasodilation
11. 6-minute walk test
12. Computer pulse oximetry (PulseOx 7500 (SPO medical, Israel)
13. Adherence to Treatment: Counting remaining pills and completing the Morisky-Green
Questionnaire
14. Assessment of quality of life: Seattle Angina Questionnaire (SAQ), Minnesota LIGE
with Heart Failure Questionnaire, Clinical Status Assessment Scale (CASA),
analog-visual scale.
15. Assessment of physical activity International Questionnaire On Physical Activity -
IPAQ
16. Hospital Anxiety and Depression Scale (HADS)
Endpoint assessment The end point is understood as the development of repeated AMI,
unstable angina pectoris, PCI for a new atherosclerotic plaque, hospitalization due to
chronic heart failure (CHF) exacerbation, the development of a new case of CHF II-IV NYHA
class, death.
Drug: Atorvastatin 80mg
Initially, hypolipidemic treatment with atorvastatin at a dose of 80 mg / day is
prescribed from the first 24-96 hours of myocardial infarction in addition to standard
therapy for the disease.
Other Name: Atorvastatin
Drug: Atorvastatin-Ezetimibe
In the absence of reaching the target level of LDL-C ≤1.4 mmol / L and ≥50% of the
initial level after 4-6 weeks from the onset of myocardial infarction, patients
additionally receive ezetimibe at a dose of 10 mg 1 time / day.
Other Name: Atorvastatin
Inclusion Criteria:
1. Signed informed consent
2. Patients of both genders aged 30 to 70 years
3. The presence of one of the options for a combination of confirmed myocardial
infarction and new coronavirus infection:
3.1. Myocardial infarction that developed within 30 days from the onset of COVID-19 - in
case of mild to moderate course or within 60 days - in case of severe course.
3.2. Development of a confirmed case of COVID-19 within 30 days from the myocardial
infarction onset.
4.1. Clinical manifestations of acute respiratory infection (body t> 37.5 ° C and one or
more signs: cough, dry or moist sputum, shortness of breath, chest tightness, SpO2 ≤ 95%,
sore throat, mild or moderate rhinorrhea, impaired or loss of smell (hyposmia or
anosmia), loss of taste (dysgeusia), conjunctivitis, weakness, muscle pain, headache,
vomiting, diarrhea, skin rash) in the presence of at least one of the epidemiological
signs:
- returning from a foreign trip 14 days before the onset of symptoms;
- having close contacts in the last 14 days with a person under surveillance for
COVID-19 who subsequently fell ill;
- having close contacts in the last 14 days with a person with a laboratory confirmed
diagnosis of COVID-19;
- having professional contacts with people who have a suspected or confirmed case of
COVID-19.
4.2. The presence of clinical manifestations specified in 4.1, in combination with
changes in the lungs according to computed tomography data, regardless of the results of
a single laboratory study for the presence of SARS-CoV-2 RNA and an epidemiological
history, or if it is impossible to conduct a laboratory study for the presence of
SARS-RNA CoV-2.
4.3. A positive laboratory test result for the presence of SARS-CoV-2 RNA using nucleic
acid amplification methods (NAA) or SARS-CoV-2 antigen using immunochromatographic
analysis, regardless of clinical manifestations.
4.4. Positive result for IgA or IgM, or IgM with IgG in patients with clinically
confirmed COVID-19 infection.
Primary STEMI or NSTEMI, confirmed by a diagnostically significant increase in
cardiospecific enzymes (5.1) in combination with at least one criterion of acute
myocardial ischemia (item 5.2):
5.1. An increase and / or decrease of serum cardiac troponin level, which should at least
once exceed the 99th percentile of the URL in patients without an initial increase of
serum cardiac troponin level, or its increase> 20% with an initially increased level of
cardiac troponin, if up to it remained stable (variation < 20%) or declined.
5.2. Typical anginal attack / acute ischemic changes on the ECG / the appearance of
pathological Q waves on the ECG / EchoCG confirmation of the presence of new areas of the
myocardium with impaired local contractility / detection of intracoronary thrombosis in
coronary angiography.
Presence of type 1 myocardial infarction (6.1) or type 2 (6.2), confirmed by coronary
angiography:
6.1. Atherothrombosis of an infarct-related artery with a sharp decrease in blood flow
distal to the damaged atherosclerotic plaque or distal embolization with thrombotic
masses / fragments of atherosclerotic plaque, followed by the development of myocardial
necrosis; or intramural hematoma in a damaged atherosclerotic plaque with a rapid
increase in its volume and a decrease in the lumen of the artery).
6.2. Myocardial infarction developed as a result of ischemia caused by non-thrombotic
complications of coronary atherosclerosis. Pathophysiologically, such myocardial
infarctions are associated with an increase in myocardial oxygen demand and / or a
decrease in its delivery to the myocardium, for example, due to coronary artery embolism,
spontaneous coronary artery dissection, respiratory failure, anemia, cardiac arrhythmias,
arterial hypertension or hypotension, etc.
Duration of subsequent hospitalization after inclusion in the study - at least 5 days
Exclusion Criteria:
1. Hemodynamically significant stenosis of the left coronary artery> 30%.
2. Recurrent or repeated STEMI or NSTEMI.
3. Exogenous hypertriglyceridemia (type 1 hyperchylomicronemia - TC / TG <0.15).
4. Acute heart failure III-IV.
5. Individual intolerance to statins, ezetimibe, alirocumab.
6. Congenital and acquired heart defects.
7. Non-sinus rhythm, artificial pacemaker.
8. Sinoatrial and atrioventricular block of 2-3 degrees.
9. QRS complex> 100 ms.
10. Complete blockade of left or right bundle branch.
11. History of CHF III-IV class according to NYHA.
12. The presence of pronounced LV hypertrophy according to echocardiography (IVS / LVS>
14 mm).
13. Uncontrolled hypertension with SBP> 180 mm Hg. and DBP> 110 mm Hg.
14. Diabetes mellitus type 1 or type 2 requiring insulin therapy.
15. Presence of anemia at the time of screening (Hb <100 g / l)
16. Chronic kidney disease (GFR < 30 ml / min / 1.73 m2 according to the CKD-EPI
formula).
17. Uncorrected thyroid dysfunction in the presence of hyper- / hypothyroidism.
18. Body mass index (BMI) ≥35 kg / m2.
19. Pregnancy, lactation.
20. Alcohol abuse, drug use.
21. Other severe concomitant diseases that exclude the possibility of participation in
the study.
22. Participation in other clinical trials within the previous 2 months.
Valentin Oleynikov
Penza, Russian Federation
Valentin Oleynikov, Principal Investigator
Penza State University