After being infected with Covid-19, many people developed to Brain fog. The treatmentstrategy now is based on the presumed pathological phenomenon and the physician'sclinical experience. Acupuncture has been used to improve cognitive dysfunction caused bycentral nervous system diseases for many years.A randomized rater-blinded controlled study is proposed to see the efficacy ofacupuncture for brain fog.
After being infected with Covid-19, many people develop cognitive dysfunction, including
deficits in attention, executive ability, language, processing speed, and memory. These
symptoms are collectively known as Brain fog or Covid fog.
The pathological mechanism of the cognitive deficit is inconclusive. Therefore, the
treatment strategy is based on the presumed pathological phenomenon and the physician's
clinical experience. Acupuncture has been used to improve cognitive dysfunction caused by
central nervous system diseases for many years. This study aims to evaluate the medium
and long-term clinical efficacy of acupuncture in patients with post-Covid related Mild
cognitive impairment (MCI).
A randomized rater-blinded controlled study is proposed. Eligible patients were over 18
years old and <65 years old. These patients were diagnosed with Covid-19 more than 12
weeks earlier and developed mild cognitive impairment (MCI) after the diagnosis of
Covid-19. Divided into the acupuncture group and the sham acupuncture group for an 8-week
course of treatment, the Mini-Mental State Examination (MMSE), the quality of life
assessment scale The 5-level EQ(EuroQol Group)- five dimensions version(EQ-5D-5L) and The
Stroop Color and Word Test evaluates the degree of cognitive impairment and the impact of
cognitive impairment on quality of life and attention.
Other: Acupuncture
Acupuncture is performed using acupuncture points recorded in traditional Chinese
medicine books as helpful for cognitive impairment.
Inclusion Criteria:
1. Have been tested positive for severe acute respiratory syndrome coronavirus
2(SARS-CoV-2) or had serum antibody positivity more than 12 weeks before.
2. Present cognitive impairment after been diagnosed as Covid-19
3. Clinical Dementia Rating (CDR) score of 1
4. Normal activities of daily living score (ADL)
5. (Mini-Mental State Examination) MMSE score of 24-28
6. Age of 18-65 years
7. Signed informed consent
Exclusion Criteria:
1. Diagnosed with any type of dementia.
2. A history of acute or chronic cerebrovascular disease, encephalitis, Parkinson's
disease, Leukoencephalopathy, and other central nervous system diseases
3. A history of hypothyroidism, vitamin B12 deficiency, depression, syphilis, and other
diseases that may affect cognitive decline.
4. Severe hearing and visual impairment, inability to complete neuropsychological tests
5. Impaired liver and kidney function and hematopoietic system disorders
Not Provided
Not Provided