A. Treatment of patients in P1 and P2 before entering the operating room:

1. Every patient who meets the eligibility criteria will be asked for consent to become
a subject of this study. Proof of consent is the signing of a letter of willingness
to become a subject of the study by the informant, the consent giver, and one
witness. Quality of Recovery using QoR 40 form will evaluate before surgery and 24
hours after surgery.

2. Patients have been fasted for 8 hours from solid food before surgery, clear water up
to 2 hours before surgery. The infusion is installed 2 hours before the patient is
sent to the operating room using an 18G intravenous catheter with Ringer lactate
fluid at a rate of administration according to the patient weight 10 ml/kg/hour

B. Treatment of patients in the operating room P1 and P2:

1. General anesthesia was performed in both groups.

2. General anesthesia begins with preoxygenation for 3-5 minutes with 100% O2.

3. Continued induction using intravenous propofol 2 mg/kgBW and intravenous fentanyl 2
mcg/kgBW.

4. After the patient is induced, continue by giving the muscle relaxant atracurium 0.5
mg/kgBW intravenously.

5. After three minutes, laryngoscopy and intubation are performed using an endotracheal
tube (ETT) with a size according to the patient needs.

6. Maintain anesthesia with oxygen and compressed air with a ratio of 1 liter: 1 liter
and sevoflurane.

7. All patients were performed with the same laparoscopic cholecystectomy procedure
(4-port technique), umbilical port (5mm), infraxiphoidal (15-20 mm), lateral
intersection of the umbilicus and axillary line (5 mm), and symmetrical assistant
port (5 mm). With a pneumoperitoneum pressure of 10-12 mmHg.

8. Continue with the operation until completion. One hour before the surgery is
completed, the patient is given anti-vomiting prophylaxis ondansetron 0.1 mg/kgBW
intravenously.

Group P1:

1. Continue with preparation for the block procedure on the patient.

2. After the necessary tools and materials are ready, the Anesthesiologist who will
perform the block washes his hands sterilely, uses a sterile gown and gloves.

3. Then the area of action is disinfected, with the sequence of 70% alcohol, betadine,
70% alcohol then a sterile hole drape is installed.

4. Identification of the place to perform the block is carried out, namely between the
midclavicular line and the anterior axillary. The injection identification guide
uses ultrasound.

5. The ultrasound machine uses a linear probe placed on the chondrium with a sagittal
cut at Costa 10, identifying the external oblique muscle, internal oblique,
transversus abdominis, costal cartilage. Stimuplex 22Gx50mm is injected using the
in-plane technique. The tip of the needle is placed under the chondrium.

6. Before injecting local anesthetic drugs, negative aspiration (exclusion of
intravascular injection) and hydrodissection using 0.9% NaCl as much as 1 - 2 ml are
performed to further ensure the area of the needle tip. Local anesthetic bupivacaine
0.25% as much as 20 ml is then injected into the field.

7. After the needle injection is removed, a block is performed with the same procedure
on the opposite side.

8. Evaluation of the success of the M-TAPA block is carried out and monitor the
occurrence of blood vessel puncture, hypotension, desaturation, and bradycardia.

9. If hypotension occurs, if the pulse rate is ≥ 60 x / minute, bolus phenylephrine 50
mcg, if the pulse rate is > 60 x / minute, bolus ephedrine 4 mg IV until the mean
arterial pressure (MAP) returns to the baseline value. If there is no improvement,
it can be repeated at 5-minute intervals. If hypotension persists, norepinephrine is
given by titration at a dose of 0.1 mcg / kgBW / minute.

10. If bradycardia occurs with unstable hemodynamics, the patient is given an
intravenous injection of atropine sulfate 0.5 mg.

11. If desaturation occurs, perform a physical examination for signs of pneumothorax
(lung sounds disappear, hyperresonant percussion), if tension pneumothorax occurs,
perform needle decompression then consult a colleague in cardiovascular thoracic
surgery (BTKV) for further management.

Group P2 No block is performed, after the operation is completed, extubation preparation
is carried out immediately.

Procedures P1 and P2 after surgery:

1. After the block is completed, the patient is given an injection of neostigmine and
atropine sulfate to antagonize the remaining atracurium drug still in the patient's
body. The patient is extubated after the patient's breathing is adequate and the
airway is clear.

2. The patient is observed in the recovery room for 2 hours and transferred to the room
if there are no complaints and the Aldrete score is ;9. The pain scale using Numeric
Rating Scale is evaluated for the first 0 hours in the recovery room. Observations
in the recovery room include: patient complaints, blood pressure, pulse, ECG,
respiratory rate and peripheral saturation are carried out every 15 minutes until
the patient is transferred to the room. The observation results are recorded on the
patient's anesthesia record sheet.

3. After the patient moves to the room, the acute pain service (APS) team will evaluate
the pain scale with Numeric Rating Scale (NRS) at 2, 12, 24 hours postoperatively
and the total opioid consumption data on the PCA machine will be recorded.

4. Quality of Recovery will evaluate again 24 hours Post Operative.