This study evaluated the effect of integrated traditional Chinese and Western medicine inthe treatment of Severe COVID-19. The patients were randomly divided into experimentalgroup and control group.
In this study, a multi center randomized controlled trial design was adopted, and the
subjects were randomly divided into the experimental group and the control group. The
control group was treated with western medicine conventional treatment plus traditional
Chinese medicine decoction simulant, while the experimental group was treated with
traditional Chinese medicine syndrome differentiation treatment decoction. The course of
treatment was 14 days and the patients were followed up for 3 months. The clinical effect
of integrated traditional Chinese and Western medicine treatment was evaluated from the
aspects of 28 day mortality, 28 days without invasive mechanical ventilation, invasive
mechanical ventilation rate, 28 days without ICU stay, clinical stability time, length of
hospital stay, quality of life, SOFA score, etc., to clarify the clinical efficacy of
integrated traditional Chinese and Western medicine treatment for Severe COVID-19
infection.
Drug: TCM plus conventional drug
All patients were treated according to international guidelines. The Experimental group
will receive TCM according to the TCM syndrome.
Drug: TCM placebo plus conventional drug
All patients were treated according to international guidelines. The control group will
receive TCM placebo according to the TCM syndrome.
Inclusion Criteria:
- accord with the diagnosis of severe/critical novel coronavirus infection;
- Age > 18 years old;
- TCM syndrome differentiation diagnosis by the attending physician or above or two
attending physicians for diagnosis and consensus;
- Sign the informed consent form.
Exclusion Criteria:
- Pregnant and lactating women;
- Trauma, hematological malignancies, various solid tumors and obstetric
complications;
- Dementia, various mental patients and those who are unwilling to cooperate;
- The patient is expected to die within the next 24 hours;
- Combined with neuromuscular diseases affecting respiratory and motor functions;
- people who have been bedridden for a long time for various reasons;
- Clinical trial participants who are taking part in other intervention measures;
- Those who are known to be allergic to the therapeutic drugs in this study.
The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
Zhengzhou 1784658, Henan 1808520, China
Not Provided