Official Title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Event-Driven Study to Investigate the Effect of Retatrutide on the Incidence of Major Adverse Cardiovascular Events and Major Adverse Kidney Events in Participants With Body Mass Index ≥27 kg/m2 and Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease
Brief Summary

The main purpose of this study is to determine if retatrutide can significantly lower theincidence of serious heart-related complications or prevent the worsening of kidneyfunction. The trial will enroll adults with body mass index 27 kg/m^2 or higher andAtherosclerotic Cardiovascular Disease and/or chronic kidney disease. The study will lastfor about 5 years. Participants will have up to 27 clinic visits with the study doctor.

Detailed Description

Not Provided

Recruiting
Atherosclerotic Cardiovascular Disease (ASCVD)
Chronic Kidney Disease (CKD)

Drug: Retatrutide

Administered SC
Other Name: LY3437943

Drug: Placebo

Administered SC

Eligibility Criteria

Inclusion Criteria:

- Participants may be without type 2 diabetes (T2D), or with T2D if their hemoglobin
A1c (HbA1c) is 10% or lower

- Participants have established atherosclerotic cardiovascular disease (ASCVD) and/or
chronic kidney disease (CKD), as evidenced at least one of the following:

- Coronary artery disease

- Cerebrovascular disease

- Peripheral arterial disease

- Chronic kidney disease defined as:

- eGFR <45 millilitres/minute/1.73 meter squared (mL/min/1.73m^2) and UACR
>30 milligram/gram (mg/g) (0.030 mg/mg)

- eGFR <60 mL/min/1.73 m^2 and UACR >100 mg/g (0.100 mg/mg), or

- eGFR <75 mL/min/1.73 m^2 and UACR >300 mg/g (0.300 mg/mg) (eGFR is
calculated by central lab based on Chronic Kidney Disease Epidemiology
Collaboration (CKD-EPI) creatinine-cystatin c equation as determined by
central lab)

- A Body Mass Index of ≥27.0 kilograms per meter squared (kg/m^2)

Exclusion Criteria:

Diabetes related:

- Participants have Type 1 Diabetes or any history of diabetic ketoacidosis

CV related:

- Participants have any of the following cardiovascular conditions ≤ 90 days prior to
randomization:

- Myocardial infarction

- Acute coronary syndrome

- Stroke, or

- Coronary, peripheral, or carotid artery arterial revascularization procedure.

- Have acute decompensated heart failure requiring hospitalization.

- Have New York Heart Association (NYHA) Classification Class IV heart failure at
screening

Kidney related:

- Participants have an eGFR <20 mL/min/1.73 m^2 at screening

- Have UACR >5000 mg/g (5.000 mg/mg) at screening

- Have received any form of dialysis ≤ 90 days from the date of randomization

- Have either undergone a kidney transplant or have a transplant procedure scheduled

Other medical conditions:

- Participants have had or plan to have a surgical treatment for obesity,

- Have a history of chronic or acute pancreatitis

- Have a family or personal history of medullary thyroid carcinoma or multiple
endocrine neoplasia (MEN) syndrome type 2

- Have a known clinically significant gastric emptying abnormality, such as severe
gastroparesis or gastric outlet obstruction

Eligibility Gender
All
Eligibility Age
Minimum: 45 Years ~ Maximum: N/A
Countries
Argentina
Australia
Austria
Belgium
Brazil
Bulgaria
Canada
Colombia
Czechia
Denmark
France
Germany
Greece
Hungary
India
Israel
Italy
Mexico
Netherlands
New Zealand
Peru
Poland
Puerto Rico
Romania
Slovakia
Spain
Turkey
Ukraine
United Kingdom
United States
Locations

Central Research Associates
Birmingham, Alabama, United States

Alliance for Multispecialty Research, LLC
Daphne, Alabama, United States

Nephrology Consultants
Huntsville, Alabama, United States

Alliance for Multispecialty Research, LLC
Mobile, Alabama, United States

Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC
Gilbert, Arizona, United States

AMZERN Clinical Trial Organization
Glendale, Arizona, United States

Arizona Kidney Disease & Hypertension Center (AKDHC) - Thunderbird
Glendale, Arizona, United States

Helios Clinical Research - SAZ-PDV-026
Paradise Valley, Arizona, United States

Banner University Medical Center Phoenix
Phoenix, Arizona, United States

Phoenix Clinical LLC
Phoenix, Arizona, United States

Arizona Cardiovascular Research Center
Phoenix, Arizona, United States

Elite Clinical Studies, LLC
Phoenix, Arizona, United States

Absolute Clinical Research
Phoenix, Arizona, United States

Scottsdale Clinical Trials
Scottsdale, Arizona, United States

Clinical Research Institute of Arizona (CRI) - Sun City West
Sun City West, Arizona, United States

Synexus Clinical Research US, Inc./Orange Grove Family Practice
Tucson, Arizona, United States

Cardiology and Medicine Clinic
Little Rock, Arkansas, United States

Kidney & Hypertension Center - Apple Valley
Apple Valley, California, United States

Invivo - Bakersfield
Bakersfield, California, United States

AHF Westside
Beverly Hills, California, United States

American Institute of Research
Beverly Hills, California, United States

Hope Clinical Research, Inc.
Canoga Park, California, United States

Valley Clinical Trials, Inc.
Covina, California, United States

North Coast Cardiology
Encinitas, California, United States

Neighborhood Healthcare Institute of Health
Escondido, California, United States

HB Clinical Trials - Fountain Valley
Fountain Valley, California, United States

Care Access - Huntington Beach
Huntington Beach, California, United States

Irvine Clinical Research
Irvine, California, United States

Scripps Whittier Diabetes Institute
La Jolla, California, United States

Long Beach Research Institute
Long Beach, California, United States

Ark Clinical Research
Long Beach, California, United States

Cedars-Sinai Medical Center
Los Angeles, California, United States

North America Research Institute
Lynwood, California, United States

Valley Clinical Trials, Inc.
Northridge, California, United States

Desert Oasis Healthcare Medical Group
Palm Springs, California, United States

California Liver Research Institute
Pasadena, California, United States

Western University of Health Sciences
Pomona, California, United States

California Kidney Specialists
San Dimas, California, United States

Southern California Clinical Research
Santa Ana, California, United States

Care Access - Santa Clarita
Santa Clarita, California, United States

Encompass Clinical Research
Spring Valley, California, United States

Valiance Clinical Research
Tarzana, California, United States

Care Access - Thousand Oaks
Thousand Oaks, California, United States

Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc.
Toluca Lake, California, United States

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, California, United States

UCLA South Bay Endocrinology
Torrance, California, United States

InvivoCure
Van Nuys, California, United States

National Institute of Clinical Research (NICR) - High Desert
Victorville, California, United States

Synexus Clinical Research US, Inc.
Vista, California, United States

Millennium Clinical Trials
Westlake Village, California, United States

Western Nephrology
Arvada, Colorado, United States

University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States

Cardiology Associates of Fairfield County, P.C.
Stamford, Connecticut, United States

Chase Medical Research, LLC
Waterbury, Connecticut, United States

Excel Medical Clinical Trials
Boca Raton, Florida, United States

Fleming Island Center for Clinical Research
Fleming Island, Florida, United States

Jellinger and Lerman, MD PA dba The Center for Diabetes and Endocrine Care
Fort Lauderdale, Florida, United States

Florida Kidney Physicians - Fort Lauderdale
Fort Lauderdale, Florida, United States

East Coast Institute for Research, LLC
Jacksonville, Florida, United States

Inpatient Research Clinic
Miami Lakes, Florida, United States

Suncoast Research Group
Miami, Florida, United States

New Age Medical Research Corporation
Miami, Florida, United States

Elixia Central Florida
Orlando, Florida, United States

Omega Research Orlando
Orlando, Florida, United States

Florida Kidney Physicians, LLC
Port Charlotte, Florida, United States

Florida Kidney Physicians - Tampa
Riverview, Florida, United States

Cardiovascular Center of Sarasota
Sarasota, Florida, United States

Care Access - Tamarac
Tamarac, Florida, United States

Palm Harbor Dermatology PA d/b/a TrueBlue Clinical Research
Tampa, Florida, United States

Care Access - Tampa
Tampa, Florida, United States

American Clinical Trials - Acworth
Acworth, Georgia, United States

Atlanta Diabetes Associates
Atlanta, Georgia, United States

Emory University School of Medicine
Atlanta, Georgia, United States

Fides Clinical Research
Atlanta, Georgia, United States

Southeastern Clinical Research Institute
Augusta, Georgia, United States

American Clinical Trials - Douglasville
Douglasville, Georgia, United States

Center for Advanced Research & Education
Gainesville, Georgia, United States

East Coast Institute for Research, LLC
Macon, Georgia, United States

North Georgia Clinical Research
Woodstock, Georgia, United States

Great Lakes Clinical Trials - Ravenswood
Chicago, Illinois, United States

Clinical Investigation Specialists
Gurnee, Illinois, United States

Accellacare - DuPage
Lombard, Illinois, United States

Alliance for Multispecialty Research, LLC
Park Ridge, Illinois, United States

Rockford Nephrology Associates
Rockford, Illinois, United States

Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative
Springfield, Illinois, United States

Qualmedica Research, LLC
Evansville, Indiana, United States

Nephrology Associates of Northern Illinois and Indiana (NANI) - Fort Wayne
Fort Wayne, Indiana, United States

Indiana University Health Methodist Hospital
Indianapolis, Indiana, United States

Care Access - South Indianapolis
Indianapolis, Indiana, United States

Nephrology Associates of Northern Illinois and Indiana - IKS - Indianapolis South
Indianapolis, Indiana, United States

Reid Physician Associates
Richmond, Indiana, United States

Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, United States

The University of Kansas - Clinical Research Center
Fairway, Kansas, United States

Alliance for Multispecialty Research, LLC
Newton, Kansas, United States

Cotton O'Neil Clinical Research Center
Topeka, Kansas, United States

Cotton O'Neil Diabetes & Endocrinology
Topeka, Kansas, United States

Qualmedica Research
Bowling Green, Kentucky, United States

Alliance for Multispecialty Research, LLC
Lexington, Kentucky, United States

L-MARC Research Center
Louisville, Kentucky, United States

Christus Health Research Center
Alexandria, Louisiana, United States

Care Access - Lake Charles
Lake Charles, Louisiana, United States

IMA Clinical Research Monroe - Armand
Monroe, Louisiana, United States

Alliance for Multispecialty Research, LLC
New Orleans, Louisiana, United States

Care Access - Baltimore
Baltimore, Maryland, United States

Sinai Hospital Of Baltimore
Baltimore, Maryland, United States

Ascension Saint Agnes Heart Care
Baltimore, Maryland, United States

MedStar Good Samaritan Hospital
Baltimore, Maryland, United States

Jadestone Clinical Research
Beltsville, Maryland, United States

Anderson Medical Research
Fort Washington, Maryland, United States

MedStar Health Research Institute (MedStar Physician Based Research Network)
Hyattsville, Maryland, United States

Care Access - Dorchester
Dorchester, Massachusetts, United States

NECCR PrimaCare Research
Fall River, Massachusetts, United States

Revival Research Institute, LLC
Dearborn, Michigan, United States

Elixia MKC, LLC
Pontiac, Michigan, United States

Lake Michigan Nephrology
Saint Joseph, Michigan, United States

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, United States

Alliance for Multispecialty Research, LLC
Kansas City, Missouri, United States

StudyMetrix Research
Saint Peters, Missouri, United States

Clinvest Headlands Llc
Springfield, Missouri, United States

Mercy Research - Smith Glynn Callaway
Springfield, Missouri, United States

Mercury Street Medical Group, PLLC
Butte, Montana, United States

Boeson Research MSO
Missoula, Montana, United States

Henderson Clinical Trials
Henderson, Nevada, United States

DaVita Clinical Research - Las Vegas
Las Vegas, Nevada, United States

Excel Clinical Research, LLC
Las Vegas, Nevada, United States

Alliance for Multispecialty Research, LLC
Las Vegas, Nevada, United States

Advanced Biomedical Research of America - South Eastern Avenue
Las Vegas, Nevada, United States

Vector Clinical Trials
Las Vegas, Nevada, United States

Albany Medical College, Division of Community Endocrinology
Albany, New York, United States

Capital Cardiology Associates
Albany, New York, United States

Westchester Medical Center Advanced Physicians Service
Kingston, New York, United States

Long Island Cardiovascular Consultants
Lake Success, New York, United States

NYU Langone Health
New York, New York, United States

Icahn School of Medicine at Mount Sinai
New York, New York, United States

Northwell Health Physician Peconic
Riverhead, New York, United States

Saratoga Clinical Research
Saratoga Springs, New York, United States

Staten Island University Hospital
Staten Island, New York, United States

Stony Brook University
Stony Brook, New York, United States

Care Access - Fayetteville
Fayetteville, North Carolina, United States

Medication Management
Greensboro, North Carolina, United States

Physician's East Endocrinology
Greenville, North Carolina, United States

IMA Clinical Research - Lenoir
Lenoir, North Carolina, United States

West Clinical Research
Morehead City, North Carolina, United States

Accellacare - Raleigh
Raleigh, North Carolina, United States

Accellacare - Wilmington - 1917 Tradd Court
Wilmington, North Carolina, United States

Advanced Medical Research
Maumee, Ohio, United States

Alliance for Multispecialty Research, LLC
Norman, Oklahoma, United States

Good Samaritan Regional Medical Center
Corvallis, Oregon, United States

Heritage Valley Multispecialty Group, Inc
Beaver, Pennsylvania, United States

Northeast Clinical Research Center
Bethlehem, Pennsylvania, United States

Capital Area Research, LLC
Camp Hill, Pennsylvania, United States

Geisinger Medical Center
Danville, Pennsylvania, United States

Lancaster General Hospital
Lancaster, Pennsylvania, United States

Clinical Research of Philadelphia
Philadelphia, Pennsylvania, United States

Tristar Clinical Investigations
Philadelphia, Pennsylvania, United States

Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair
Pittsburgh, Pennsylvania, United States

Guthrie Medical Group, P.C.
Sayre, Pennsylvania, United States

Clinical Renal Associates - Panoramic Science
Upland, Pennsylvania, United States

Medical University of South Carolina
Charleston, South Carolina, United States

Accellacare Trident Cardiology
Charleston, South Carolina, United States

Walker Family Care
Little River, South Carolina, United States

Care Access - Mauldin
Mauldin, South Carolina, United States

Circle Clinical Research
Sioux Falls, South Dakota, United States

Alliance for Multispecialty Research, LLC
Knoxville, Tennessee, United States

Care Access - Memphis
Memphis, Tennessee, United States

IMA Clinical Research Austin
Austin, Texas, United States

Headlands Research - Brownsville
Brownsville, Texas, United States

South Texas Clinical Research
Corpus Christi, Texas, United States

Private Practice - Dr. Osvaldo A. Brusco
Corpus Christi, Texas, United States

Baylor Soltero CV Research Center
Dallas, Texas, United States

Velocity Clinical Research, Dallas
Dallas, Texas, United States

North Texas Endocrine Center
Dallas, Texas, United States

Renal Disease Research Institute
Dallas, Texas, United States

UT Southwestern Medical Center
Dallas, Texas, United States

Soma Clinical Trials
Denison, Texas, United States

South Texas Research Institute
Edinburg, Texas, United States

Medresearch Inc
El Paso, Texas, United States

Diabetes and Thyroid Center of Ft. Worth
Fort Worth, Texas, United States

Valley Institute of Research - Fort Worth
Fort Worth, Texas, United States

Juno Research
Houston, Texas, United States

Biopharma Informatic, LLC
Houston, Texas, United States

Aqua Research Institute
Houston, Texas, United States

Northwest Houston Cardiology - Cypress
Houston, Texas, United States

Clinical Trial Network
Houston, Texas, United States

PlanIt Research, PLLC
Houston, Texas, United States

Biopharma Informatic, LLC
Houston, Texas, United States

Research Physicians Network, LLC
Houston, Texas, United States

Accurate Clinical Research, Inc
Humble, Texas, United States

Texas Institute for Kidney and Endocrine Disorders
Lufkin, Texas, United States

Wellness Clinical Research
McKinney, Texas, United States

PRX Research
Mesquite, Texas, United States

Southern Endocrinology Associates
Mesquite, Texas, United States

National Institute of Clinical Research (NICR) - San Antonio - South Laredo Street
San Antonio, Texas, United States

Clinical Advancement Center
San Antonio, Texas, United States

Discovery Clinical Trials - San Antonio
San Antonio, Texas, United States

IMA Clinical Research San Antonio
San Antonio, Texas, United States

Endeavor Clinical Trials
San Antonio, Texas, United States

DaVita Clinical Research - North Houston
Shenandoah, Texas, United States

Revival Research Institute, LLC
Sherman, Texas, United States

Medrasa Clinical Research
Wylie, Texas, United States

Alpine Research Organization
Clinton, Utah, United States

Alliance for Multispecialty Research, LLC
Layton, Utah, United States

Synexus Clinical Research US, Inc.
Salt Lake City, Utah, United States

Utah Kidney Research Institute
Salt Lake City, Utah, United States

Alliance for Multispecialty Research, LLC
Norfolk, Virginia, United States

Dominion Medical Associates, Inc.
Richmond, Virginia, United States

Eastside Research Associates
Redmond, Washington, United States

Universal Research Group
Tacoma, Washington, United States

IMA Clinical Research West Virginia
Morgantown, West Virginia, United States

St. Vincent Hospital d/b/a Prevea Health
Green Bay, Wisconsin, United States

Clinical Investigation Specialists
Kenosha, Wisconsin, United States

CEDIC
Caba, Buenos Aires, Argentina

Instituto Médico Especializado (IME)
Caba, Buenos Aires, Argentina

Centro de Investigaciones Metabólicas (CINME)
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

IDIM - Instituto de Investigaciones Metabólicas
Ciudad de Buenos Aires, Buenos Aires, Argentina

Centro Médico Lebensohn
Junín, Buenos Aires, Argentina

Hospital Italiano de La Plata
La Plata, Buenos Aires, Argentina

CIMeL
Lanus, Buenos Aires, Argentina

Centro de Investigaciones Médicas Mar del Plata
Mar del Plata, Buenos Aires, Argentina

Instituto de Investigaciones Clínicas Mar del Plata
Mar del Plata, Buenos Aires, Argentina

Clínica Privada Independencia
Munro, Buenos Aires, Argentina

Instituto De Investigaciones Clinicas Quilmes
Quilmes, Buenos Aires, Argentina

DIM Clínica Privada
Ramos Mejía, Buenos Aires, Argentina

Corporación Médica San Martín
San Martín, Buenos Aires, Argentina

Go Centro Medico San Nicolás
San Nicolas, Buenos Aires, Argentina

Centro de Investigaciones Medicas Temperley
Temperley, Buenos Aires, Argentina

CEREHA
Villa Dominico, Buenos Aires, Argentina

Instituto de Investigaciones Clinicas Zarate
Zárate, Buenos Aires, Argentina

Stat Research S.A.
Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina

Investigaciones Medicas Imoba Srl
Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina

CIPREC
Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina

CIPREC
Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina

Centro Médico Viamonte
Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina

Mautalen Salud e Investigación
Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina

Glenny Corp. S.A.
Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina

CEMEDIAB
C.a.b.a., Ciudad Autónoma De Buenos Aires, Argentina

Consultorio de Investigación Clínica EMO SRL
Ciudad Autonoma de Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina

Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
Ciudad Autonoma de Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina

Centro Medico Privado CEMAIC
Capital, Córdoba, Argentina

Centro Medico Privado San Vicente Diabetes
Cordoba, Córdoba, Argentina

Instituto Médico Río Cuarto
Río Cuarto, Córdoba, Argentina

Centro de Salud e Investigaciones Médicas
Santa Rosa, La Pampa, Argentina

CIPADI - Centro Integral de Prevencion y Atencion en Diabetes
Godoy Cruz, Mendoza, Argentina

Polo de Salud Vistalba
Luján de Cuyo, Mendoza, Argentina

Centro de Investigaciones Clínicas Baigorria
Granadero Baigorria, Santa Fe, Argentina

Fundacion Estudios Clinicos
Rosario, Santa Fe, Argentina

INECO Neurociencias Oroño
Rosario, Santa Fe, Argentina

Instituto Especialidades de la Salud Rosario
Rosario, Santa Fe, Argentina

Instituto Médico Catamarca IMEC
Rosario, Santa Fe, Argentina

Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica
Rosario, Santa Fe, Argentina

Instituto de Investigaciones Clinicas Rosario
Rosario, Santa Fe, Argentina

Laboratorio de Hemostasia y Trombosis
Rosario, Santa Fe, Argentina

Hospital Provincial del Centenario
Rosario, Santa Fe, Argentina

Sanatorio San Martin
Venado Tuerto, Santa Fe, Argentina

Centro de Investigaciones Médicas Tucuman
SAN M. DE Tucuman, Tucumán, Argentina

Centro Modelo de Cardiología
San Miguel de Tucuman, Tucumán, Argentina

Investigaciones Clínicas Tucumán
San Miguel de Tucuman, Tucumán, Argentina

CONEXA Investigacion Clinica S.A.
Buenos Aires, Argentina

Buenos Aires Macula S.A
Buenos Aires, Argentina

Cardiología Palermo
Buenos Aires, Argentina

CEMEDIC
Buenos Aires, Argentina

Fundación Respirar
Buenos Aires, Argentina

Centro Diabetológico Dr. Waitman
Córdoba, Argentina

Instituto de Investigaciones Clínicas Córdoba
Córdoba, Argentina

Sanatorio Privado Duarte Quirós
Córdoba, Argentina

Centro Médico Colón
Córdoba, Argentina

CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani
Córdoba, Argentina

Centro de Diagnóstico y Rehabilitación (CEDIR)
Santa Fe, Argentina

Clínica de Nefrología, Urología y Enfermedades Cardiovasculares
Santa Fe, Argentina

Centro de Investigaciones Clinicas del Litoral
Santa Fe, Argentina

Sanatorio Norte
Santiago del Estero, Argentina

Canberra Hospital
Garran, Australian Capital Territory, Australia

Emeritus Research
Botany, New South Wales, Australia

Northern Beaches Clinical Research
Brookvale, New South Wales, Australia

The AIM Centre / Hunter Diabetes Centre
Merewether, New South Wales, Australia

Royal North Shore Hospital
St Leonards, New South Wales, Australia

University of Sydney - Charles Perkins Centre
Sydney, New South Wales, Australia

Royal Brisbane and Women's Hospital
Brisbane, Queensland, Australia

Logan Hospital
Meadowbrook, Queensland, Australia

Nightingale Research
Adelaide, South Australia, Australia

Southern Adelaide Diabetes & Endocrine Services
Oaklands Park, South Australia, Australia

Box Hill Hospital
Box Hill, Victoria, Australia

Emeritus Research
Camberwell, Victoria, Australia

Barwon Health
Geelong, Victoria, Australia

Austin Health - Repatriation Hospital
Heidelberg West, Victoria, Australia

The Alfred Hospital
Melbourne, Victoria, Australia

Fiona Stanley Hospital
Murdoch, Western Australia, Australia

Krankenhaus St. Josef Braunau
Braunau, Oberösterreich, Austria

Konventhospital der Barmherzigen Brüder Linz
Linz, Oberösterreich, Austria

Medizinische Universität Graz
Graz, Steiermark, Austria

Private Practice - Dr. Evelyn Fliesser-Gorzer
Sankt Stefan ob Stainz, Steiermark, Austria

Medizinische Universitaet Innsbruck
Innsbruck, Tirol, Austria

VIVIT
Feldkirch, Vorarlberg, Austria

Zentrum für klinische Studien Dr Hanusch Gmbh
Vienna, Wien, Austria

Universitaetsklinikum Allgemeines Krankenhaus Wien
Vienna, Wien, Austria

Imed19-privat
Vienna, Austria

Klinik Landstraße
Wien, Austria

Klinik Hietzing
Wien, Austria

Imelda General Hospital
Bonheiden, Antwerpen, Belgium

Algemeen Ziekenhuis klina
Brasschaat, Antwerpen, Belgium

Antwerp University Hospital
Edegem, Antwerpen, Belgium

Centre Hospitalier Universitaire Brugmann
Brussels, Bruxelles-Capitale, Région De, Belgium

Université Libre de Bruxelles - Hôpital Erasme
Brussels, Bruxelles-Capitale, Région De, Belgium

UZ Brussel
Brussels, Bruxelles-Capitale, Région De, Belgium

Cliniques universitaires Saint-Luc
Brussels, Bruxelles-Capitale, Région De, Belgium

Anima
Alken, Limburg, Belgium

Ziekenhuis Oost-Limburg, Campus St.-Jan
Genk, Limburg, Belgium

Jessa Ziekenhuis
Hasselt, Limburg, Belgium

Onze Lieve Vrouw Ziekenhuis Aalst
Aalst, Oost-Vlaanderen, Belgium

UZ Gent
Gent, Oost-Vlaanderen, Belgium

Kormont
Kluisbergen, Oost-Vlaanderen, Belgium

Kormont
Kluisbergen, Oost-Vlaanderen, Belgium

Kormont
Kluisbergen, Oost-Vlaanderen, Belgium

Kormont
Kluisbergen, Oost-Vlaanderen, Belgium

ZNA Jan Palfijn
Merksem, Vlaams Gewest, Belgium

UZ Leuven
Leuven, Vlaams-Brabant, Belgium

Jan Yperman ziekenhuis
Ieper, West-Vlaanderen, Belgium

AZ Groeninge Campus Kennedylaan
Kortrijk, West-Vlaanderen, Belgium

Az Damiaan vzw
Oostende, West-Vlaanderen, Belgium

AZ Delta vzw
Roeselare, West-Vlaanderen, Belgium

Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
Liège, Belgium

Centro de Pesquisas Clínicas Dr. Marco Mota
Maceio, Alagoas, Brazil

CPHOSP Manaus Medicina, Ensino e Pesquisa
Manaus, Amazonas, Brazil

Clinica Senhor do Bonfim CSB - Salvador
Salvador, Bahia, Brazil

Hospital Da Bahia
Salvador, Bahia, Brazil

Instituto de Ensino e Pesquisa Clinica do Ceara
Fortaleza, Ceará, Brazil

Instituto de Estudos e Pesquisas Clinicas do Ceara IEP-CE
Fortaleza, Ceará, Brazil

Private Practice - Dr.Miguel N. Hissa
Fortaleza, Ceará, Brazil

L2IP - Instituto de Pesquisas Clínicas
Brasília, Distrito Federal, Brazil

Chronos Pesquisa Clínica
Brasília, Distrito Federal, Brazil

CEDOES
Vitória, Espírito Santo, Brazil

Universidade Federal de Goias
Goiania, Goiás, Brazil

Santa Casa de Misericordia de Belo Horizonte
Belo Horizonte, Minas Gerais, Brazil

Consultoria em Controle de Infecção Hospitalar
Belo Horizonte, Minas Gerais, Brazil

Eurolatino Pesquisas Medicas
Uberlandia, Minas Gerais, Brazil

Cline Research Center
Curitiba, Paraná, Brazil

Quanta Diagnóstico e Terapia
Curitiba, Paraná, Brazil

PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR
Curitiba, Paraná, Brazil

Instituto Pro Renal Brasil
Curitiba, Paraná, Brazil

Centro de Diabetes Curitiba
Curitiba, Paraná, Brazil

Hospital Universitário João de Barros Barreto
Belem, Pará, Brazil

Fundação Universidade de Caxias do Sul (FUCS)
Caxias do sul, Rio Grande Do Sul, Brazil

Instituto Méderi de Pesquisa e Saúde
Passo Fundo, Rio Grande Do Sul, Brazil

Núcleo de Pesquisa Clínica do Rio Grande do Sul
Porto Alegre, Rio Grande Do Sul, Brazil

AngioCor Blumenau
Blumenau, Santa Catarina, Brazil

Centro de Pesquisa Clinica do Coracao
Aracaju, Sergipe, Brazil

Instituto de Pesquisa clinica de Campinas
Campinas, São Paulo, Brazil

Centro de Pesquisa Sao Lucas
Campinas, São Paulo, Brazil

Centro de Endocrinologia Geloneze
Campinas, São Paulo, Brazil

Centro de Pesquisa Clínica de Marília - CPCLIM
Marília, São Paulo, Brazil

Praxis Pesquisa Medica
Santo Andre, São Paulo, Brazil

Pesquisare Saude
Santo André, São Paulo, Brazil

Centro Multidisciplinar de Estudos Clinicos
Sao Bernardo do Campo, São Paulo, Brazil

Instituto de Pesquisa Clinica
Sao Paulo, São Paulo, Brazil

CPCLIN
Sao Paulo, São Paulo, Brazil

BR Trials - Ensaios Clinicos e Consultoria
Sao Paulo, São Paulo, Brazil

Hospital Alemao Oswaldo Cruz
Sao Paulo, São Paulo, Brazil

Incor - Instituto do Coracao
Sao Paulo, São Paulo, Brazil

Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, São Paulo, Brazil

ISPEM - Instituto São José dos Campos em Pesquisas Médicas
São José dos Campos, São Paulo, Brazil

Instituto de Molestias Cardiovasculares de Tatui
Tatui, São Paulo, Brazil

Integral Pesquisa e Ensino
Votuporanga, São Paulo, Brazil

IBPClin - Instituto Brasil de Pesquisa Clínica
Rio de Janeiro, Brazil

Ruschel Medicina e Pesquisa Clínica
Rio De Janeiro, Brazil

Hospital Pro-Cardiaco
Rio de Janeiro, Brazil

CPQuali Pesquisa Clínica
São Paulo, Brazil

BP - A Beneficencia Portuguesa de São Paulo
São Paulo, Brazil

IBCC - Núcleo de Pesquisa e Ensino
São Paulo, Brazil

CEPIC - Centro Paulista de Investigação Clínica
São Paulo, Brazil

Hospital das Clinicas FMUSP
São Paulo, Brazil

Diagnostic Consultative Center - 1 - Sevlievo EOOD
Sevlievo, Gabrovo, Bulgaria

Medical Center Berbatov
Ямбол, Sliven, Bulgaria

MC "Acad. Ivan Penchev"
Sofia, Sofia (stolitsa), Bulgaria

UMHATEM 'N.I. Pirogov'
Sofia, Sofia (stolitsa), Bulgaria

MHAT Botevgrad
Botevgrad, Sofia, Bulgaria

MHAT Dobrich
Dobrich, Bulgaria

Medical Center New Polyclinic Gabrovo
Gabrovo, Bulgaria

UMBAL "Kaspela"
Plovdiv, Bulgaria

University Multiprofile Hospital for Active Treatment "Sveti Georgi" EAD
Plovdiv, Bulgaria

Medical Centre Pratia Clinic EOOD
Plovdiv, Bulgaria

MC Rusemed
Ruse, Bulgaria

"University Multiprofile Hospital for Active Treatment "Aleksandrovska"" EAD"
Sofia, Bulgaria

Medical Center Hera EOOD
Sofia, Bulgaria

Medical Center Pulmovision
Sofia, Bulgaria

UMHAT "Prof. Dr. Stoyan Kirkovich"AD
Stara Zagora, Bulgaria

Diagnostic and Consultative Center Equita
Varna, Bulgaria

Medical Centre Pratia Clinic EOOD
Varna, Bulgaria

Multiprofile Regional Hospital for Active Treatment "Dr. Stefan Cherkezov" AD
Veliko Tarnovo, Bulgaria

C-health Research
Calgary, Alberta, Canada

C-health
Edmonton, Alberta, Canada

Ocean West Research Clinic
Surrey, British Columbia, Canada

SMH Cardiology Clinical Trials
Surrey, British Columbia, Canada

Seven Oaks General Hospital
Winnipeg, Manitoba, Canada

Winnipeg Clinic
Winnipeg, Manitoba, Canada

G A Research Associates
Moncton, New Brunswick, Canada

Care Access - Cape Breton
Sydney, Nova Scotia, Canada

Med Trust Research
Courtice, Ontario, Canada

St Josephs Healthcare Hamilton - West 5th Campus
Hamilton, Ontario, Canada

St. Joseph's Health Care
London, Ontario, Canada

Victoria Hospital & Children's Hospital - London Health Sciences Centre
London, Ontario, Canada

Western Centre for Public Health and Family Medicine
London, Ontario, Canada

North York Diagnostic and Cardiac Centre
North York, Ontario, Canada

Lakeridge Health
Oshawa, Ontario, Canada

Care Access - Thunder Bay - Barton Street
Thunder Bay, Ontario, Canada

Corcare
Toronto, Ontario, Canada

Toronto General Hospital
Toronto, Ontario, Canada

Clinical Research Solutions - Kitchener
Waterloo, Ontario, Canada

Winchester District Memorial Hospital
Winchester, Ontario, Canada

Ecogene-21
Chicoutimi, Quebec, Canada

Unité de Recherche Clinique du CISSS des Laurentides
St-Jerome, Quebec, Canada

Alpha Recherche Clinique
Quebec, Canada

Hospital Pablo Tobon Uribe
Medellin, Antioquia, Colombia

Clinica de la Costa S.A.S.
Barranquilla, Atlántico, Colombia

IPS Centro Científico Asistencial S.A.S
Barranquilla, Atlántico, Colombia

Hospital Universidad Del Norte
Soledad, Atlántico, Colombia

Administradora Country S.A.S - Clínica del Country
Bogotá, Cundinamarca, Colombia

Hospital Universitario Mayor Méderi
Bogotá, Distrito Capital De Bogotá, Colombia

Fundacion Cardiomet Cequin
Armenia, Quindío, Colombia

Fundación Cardiovascular de Colombia
Piedecuesta, Santander, Colombia

Clínica Imbanaco S.A.S
Cali, Valle Del Cauca, Colombia

Fundación Centro De Investigaciones Clinicas Ips Cardiomet Pereira
Pereira, Colombia

UNIVMED
Brno, Brno-město, Czechia

Vojenská Nemocnice Brno
Brno, Brno-město, Czechia

Fakultni Nemocnice u sv. Anny v Brne
Brno, Jihomoravský Kraj, Czechia

Fakultni Nemocnice u sv. Anny v Brne
Brno, Jihomoravský Kraj, Czechia

Kardio Chlumec
Chlumec nad Cidlinou, Královéhradecký Kraj, Czechia

Kardiologicka a Angiologicka Ambulance
Ostrava - Dubina, Moravskoslezský Kraj, Czechia

MaderMED
Ostrava, Moravskoslezský Kraj, Czechia

Kardiologicka ambulance
Litovel, Olomoucký Kraj, Czechia

Agentura Science Pro
Olomouc, Olomoucký Kraj, Czechia

Private Practice - Dr. Miroslav Koliba
Ostrava, Ostrava Město, Czechia

Diakom, s.r.o. - Přeštice
Přeštice, Plzeň-jih, Czechia

Poliklinika Lípa Centrum
Prague, Praha 13, Czechia

MUDr. Jana Parkanyiova
Prague, Praha 1, Czechia

Synexus Czech
Prague, Praha 2, Czechia

MEDICON
Prague, Praha 4, Czechia

Fakultni Thomayerova nemocnice
Prague, Praha 4, Czechia

Nefrologie
Prague, Praha 4, Czechia

DiaVize s.r.o.
Praha, Praha 4, Czechia

Centrum Kardiovaskularni Mediciny
Prague, Praha 6, Czechia

ResTrial s.r.o.
Praha, Praha 8, Czechia

MUDr. Barbora Diepoltova
Praha 9 - Klanovice, Praha 9, Czechia

FLEDIP - Na dlouhem lanu
Prague, Praha, Hlavní Mešto, Czechia

Diabetologie a endokrinologie, J.Venerová
Praha 6, Praha, Hlavní Mešto, Czechia

MEDICUS SERVICES s.r.o., kardiologicka ambulance
Brandýs nad Labem-Stará Boleslav, Praha-východ, Czechia

Kardioma
Kolin, Středočeský Kraj, Czechia

Clinical Trials Service s.r.o.
Uherské Hradiště, Zlínský Kraj, Czechia

EDUMED - Náchod
Náchod, Czechia

Diabetologicke centrum s.r.o.
Olomouc, Czechia

PreventaMed
Olomouc, Czechia

Kardiologicka ambulance MUDr. Ferkl s.r.o.
Trutnov, Czechia

Cardio Research, s.r.o
Zlín, Czechia

Nemocnice Cesky Krumlov
Český Krumlov, Czechia

Herlev and Gentofte Hospital
Copenhagen, Hovedstaden, Denmark

Sanos Clinic
Herlev, Hovedstaden, Denmark

Aarhus Universitetshospital, Skejby
Aarhus, Midtjylland, Denmark

Sanos Clinic - Nordjylland
Gandrup, Nordjylland, Denmark

Sygehus Sønderjylland i Aabenraa
Aabenraa, Syddanmark, Denmark

Sanos Clinic - Syddanmark
Vejle, Syddanmark, Denmark

Centre Hospitalier Universitaire de Nice - Hopital Pasteur
Nice, Alpes-Maritimes, France

Bordeaux University Hospital - Pellegrin
Bordeaux, Aquitaine, France

CHU Bordeaux Haut-Leveque
Pessac, Aquitaine, France

Centre Hospitalier Louis Pasteur
Le Coudray, Eure-et-Loir, France

CHU Rangueil
Toulouse cedex 9, Haute-Garonne, France

CHU Montpellier Lapeyronie Hospital
Montpellier, Hérault, France

Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
Tours, Indre-et-Loire, France

Chu Grenoble Alpes
La Tronche, Isère, France

Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
Nantes Cedex 1, Loire-Atlantique, France

Polyclinique Vauban
Valenciennes, Nord, France

Pitie Salpetriere University Hospital
Paris, Orne, France

Chu Gabriel Montpied
Clermont-Ferrand, Puy-de-Dôme, France

Centre Hospitalier Sud Francilien
Corbeil-Essonnes, Île-de-France, France

Groupe hospitalier Paris saint Joseph
Paris, Île-de-France, France

Hôpital Européen Georges Pompidou
Paris, Île-de-France, France

CRS Clinical Research Services Mannheim
Mannheim, Baden-Württemberg, Germany

Universitätsmedizin Mannheim
Mannheim, Baden-Württemberg, Germany

Nephrologisches Zentrum Villingen-Schwenningen
Villingen-Schwenningen, Baden-Württemberg, Germany

Praxis Sauter & Sauter & Vorbach
Wangen im Allgäu, Baden-Württemberg, Germany

ZKS Suedbrandenburg
Elsterwerda, Brandenburg, Germany

Kerckhoff-Klinik
Bad Nauheim, Hessen, Germany

Universitätsklinikum Frankfurt Goethe-Universität
Frankfurt, Hessen, Germany

Zentrum für Nieren-, Hochdruck- und Stoffwechselerkrankungen - Heidering
Hannover, Niedersachsen, Germany

Kardiologische Praxis Papenburg
Papenburg, Niedersachsen, Germany

Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen
Bad Oeynhausen, Nordrhein-Westfalen, Germany

St.-Johannes-Hospital Dortmund
Dortmund, Nordrhein-Westfalen, Germany

InnoDiab Forschung Gmbh
Essen, Nordrhein-Westfalen, Germany

Unterfrintroper Hausarztzentrum Klinische Forschung
Essen, Nordrhein-Westfalen, Germany

Institut für Diabetesforschung GmbH Münster
Münster, Nordrhein-Westfalen, Germany

Universitätsmedizin Johannes Gutenberg Universität Mainz
Mainz, Rheinland-Pfalz, Germany

Zentrum für klinische Studien
Saint Ingbert, Saarland, Germany

Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien
Dresden, Sachsen, Germany

Universitaetsklinikum Carl Gustav Carus Dresden
Dresden, Sachsen, Germany

AmBeNet GmbH
Leipzig, Sachsen, Germany

Universität zu Lübeck - Institut für Endokrinologie und Diabetes
Lübeck, Schleswig-Holstein, Germany

RED-Institut GmbH
Oldenburg, Schleswig-Holstein, Germany

emovis GmbH
Berlin, Germany

Kardiologisch-Angiologische Praxis - Herzzentrum Bremen
Bremen, Germany

Diabetes Zentrum Wilhelmsburg
Hamburg, Germany

Diabetes Zentrum Wandsbek
Hamburg, Germany

Athens Medical Center - Psychikon branch
Athens, Attikí (Region), Greece

Iatriko Paleou Falirou Medical Center
Paleo Faliro, Attikí (Region), Greece

General Hospital of Athens "G. Gennimatas"
Athens, Attikí, Greece

General Hospital of Athens Laiko
Athens, Attikí, Greece

Athens Medical Center
Athens, Attikí, Greece

G. Gennimatas General Hospital of Thessaloniki
Thessaloniki, Thessaloníki, Greece

Euromedica General Clinic of Thessaloniki
Thessaloniki, Thessaloníki, Greece

Papageorgiou General Hospital of Thessaloniki
Thessaloniki, Thessaloníki, Greece

424 Military General Training Hospital
Thessaloniki, Thessaloníki, Greece

University General Hospital of Larissa
Larissa, Thessalía, Greece

University Hospital of Ioannina
Ioannina, Ípeiros, Greece

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ
Szeged, Csongrád, Hungary

Allergo-Derm Bakos Kft
Szolnok, Jász-Nagykun-Szolnok, Hungary

Selye János Kórház
Komarom, Komárom-Esztergom, Hungary

CRU Early Phase Unit
Kistarcsa, Pest, Hungary

DRC Gyógyszervizsgáló Központ
Balatongyorok, Veszprém, Hungary

Zala Megyei Szent Rafael Kórház
Zalaegerszeg, Zala, Hungary

Szent Margit Rendelintézet
Budapest, Hungary

Óbudai Egészségügyi Centrum
Budapest, Hungary

Eszak-Pesti Centrumkorhaz-Honvedkorhaz
Budapest, Hungary

PVN Kutató Kft
Budapest, Hungary

Semmelweis University
Budapest, Hungary

Privát Doktor Egészségügyi Zrt
Budapest, Hungary

Újpesti Egészségügyi Nonprofit Kft
Budapest, Hungary

Debreceni Egyetem Klinikai Kozpont
Debrecen, Hungary

G.B. Pant Institute of Postgraduate Medical Education & Research
New Delhi, Delhi, India

Sir Ganga Ram Hospital
New Delhi, Delhi, India

Nirmal Hospital Pvt Ltd.
Surat, Gujarat, India

Shri Bachubhai Dahyabhai Mehta Mahavir Heart Institute
Surat, Gujarat, India

Life Care Hospital and Research Centre
Bangalore, Karnataka, India

Manipal Hospitals
Mysore, Karnataka, India

Government Medical College - Kozhikode
Kozhikode, Kerala, India

Kingsway Hospitals (Best Multispeciality Hospital in Nagpur)
Nagpur, Maharashtra, India

Shrikrishna Hrudayalaya And Critical Care Center
Nagpur, Maharashtra, India

All India Institute of Medical Sciences (AIIMS) - Nagpur
Nagpur, Maharashtra, India

All India Institute of Medical Sciences
Bhubaneswar, Odisha, India

Sardar Patel Medical College
Bikaner, Rajasthan, India

Medway Hospitals - Kodambakkam
Chennai, Tamil Nadu, India

Motilal Nehru Medical College Hospital
Allahabad, Uttar Pradesh, India

K care Hospital
Kanpur, Uttar Pradesh, India

LPS Institute of Cardiology
Kanpur, Uttar Pradesh, India

Dr. Ram Manohar Lohia Institute of Medical Sciences
Lucknow, Uttar Pradesh, India

Shri Mahant Indiresh Hospital
Dehradun, Uttarakhand, India

Barzilai Medical Center
Ashkelon, HaDarom, Israel

Rabin Medical Center - Hasharon Campus
Petach Tikva, HaMerkaz, Israel

Rabin Medical Center
Petah Tikva, HaMerkaz, Israel

Rabin Medical Center
Petah-Tikva, HaMerkaz, Israel

Sheba Medical Center
Ramat Gan, HaMerkaz, Israel

Sheba Medical Center
Ramat Gan, HaMerkaz, Israel

Kaplan Medical Center
Rehovot, HaMerkaz, Israel

Diabetes Medical Center
Tel Aviv, HaMerkaz, Israel

Yitzhak Shamir Medical Center
Zerifin, HaMerkaz, Israel

Rambam Health Care Campus
Haifa, HaTsafon, Israel

Bnai Zion Medical Center
Haifa, HaTsafon, Israel

Galilee Medical Center
Nahariya, HaTsafon, Israel

Sourasky Medical Center
Tel Aviv, Tell Abīb, Israel

Shaare Zedek Medical Center
Jerusalem, Yerushalayim, Israel

Hadassah Medical Center
Jerusalem, Yerushalayim, Israel

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna, Emilia-Romagna, Italy

Azienda Ospedaliero Universitaria S.Anna
Ferrara, Emilia-Romagna, Italy

AOU Policlinico Umberto I
Roma, Lazio, Italy

Ospedale San Martino
Genova, Liguria, Italy

Centro Cardiologico Monzino
Milan, Milano, Italy

IRCCS Policlinico San Donato
San Donato Milanese, Milano, Italy

Fondazione Policlinico Universitario Campus Bio-Medico
Rome, Roma, Italy

A.O.U. Policlinico Paolo Giaccone
Palermo, Sicilia, Italy

Azienda Ospedaliera Universitaria Pisana
Pisa, Toscana, Italy

Azienda Ospedaliero Universitaria Pisana
Pisa, Toscana, Italy

AO Santa Maria della Misericordia
Perugia, Umbria, Italy

IRCCS - AOU di Bologna
Bologna, Italy

Ospedale San Raffaele
Milano, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
Roma, Italy

Centro de Investigacion en Artritis y Osteoporosis SC
Mexicali, Baja California, Mexico

Centro de Investigacion Cardiovascular y Metabólica
Tijuana, Baja California, Mexico

Cryptex Investigación Clínica S.A. de C.V.
Cuauhtémoc, Ciudad De México, Distrito Federal, Mexico

RM Pharma Specialists
Mexico City, Distrito Federal, Mexico

Clínicos Asociados BOCM
Mexico City, Distrito Federal, Mexico

Hospital de Jésus, I.A.P.
Mexico City, Distrito Federal, Mexico

Cemdec SA de CV
Mexico City, Distrito Federal, Mexico

Clinica Omega
Mexico City, Distrito Federal, Mexico

Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares
Mexico City, Distrito Federal, Mexico

Private Practice - Dr. Eduardo Julián José Roberto Chuquiure Valenzuela
Mexico City, Distrito Federal, Mexico

ProcliniQ Investigación Clínica SA de CV
Mexico City, Distrito Federal, Mexico

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Mexico City, Distrito Federal, Mexico

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Mexico City, Distrito Federal, Mexico

Clinstile, S.A. de C.V.
Mexico, Distrito Federal, Mexico

Medimanage Research
Tlalpan, Distrito Federal, Mexico

Instituto Cardiovascular de León S.C.
León, Guanajuato, Mexico

Centro de Atencion al Diabetico Actopan
Actopan, Hidalgo, Mexico

Instituto Jalisciense de Investigacion en Diabetes y Obesidad
Guadalajara, Jalisco, Mexico

Diseno y Planeacion en Investigacion Medica
Guadalajara, Jalisco, Mexico

Centro de Investigacion Medica Integral
Guadalajara, Jalisco, Mexico

Centro de Investigación Clínica y Medicina Traslacional (CIMeT)
Guadalajara, Jalisco, Mexico

Private Practice - Dr. Arechavaleta Granell Maria del Rosario
Guadalajara, Jalisco, Mexico

Unidad de Investigación Clínica y Atención Médica HEPA S.C.
Guadalajara, Jalisco, Mexico

Virgen Cardiovascular Research SC
Guadalajara, Jalisco, Mexico

CINVEC Medica
Guadalajara, Jalisco, Mexico

Clinica de Enfermedades Crónicas y de Procedimientos Especiales
Morelia, Michoacán, Mexico

Instituto de Diabetes, Obesidad y Nutricion
Cuernavaca, Morelos, Mexico

Investigación Clínica Cuernavaca, S.C.
Cuernavaca, Morelos, Mexico

Investigación Nefrológica
Cuernavaca, Morelos, Mexico

Servicios de Oncología Medica Integral - Monterrey - José Benitez
Monterrey, Nuevo León, Mexico

Cardiolink Clin Trials
Monterrey, Nuevo León, Mexico

IMED Internal Medicine Clin Trials
Monterrey, Nuevo León, Mexico

Unidad biomedica avanzada monterrey
Monterrey, Nuevo León, Mexico

Clínica García Flores SC
Monterrey, Nuevo León, Mexico

Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
Monterrey, Nuevo León, Mexico

Centro de investigación y control metabólico
San Nicolás de los Garza, Nuevo León, Mexico

Centro de Investigacion Clinica de Oaxaca
Oaxaca de Juarez, Oaxaca, Mexico

Health Pharma Querétaro
Juriquilla, Querétaro, Mexico

Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C.
Culiacan, Sinaloa, Mexico

Centro de Estudios de Investigacion Metabolicos y Cardiovasculares
Ciudad Madero, Tamaulipas, Mexico

Consultorio de Medicina Especilizada del Sector Privado
Xalapa, Veracruz, Mexico

Medical Care and Research SA de CV
Merida, Yucatán, Mexico

EME RED Hospitalaria
Mérida, Yucatán, Mexico

Fundación Cardiovascular de Aguascalientes A.C.
Aguascalientes, Mexico

Enclifar Ensayos Clínicos Farmacológicos Sc
Chihuahua, Mexico

Instituto de Investigaciones Aplicadas a la Neurociencia A.C.
Durango, Mexico

Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia
Durango, Mexico

Instituto Nacional de Cardiologia Ignacio Chavez
Mexico, Mexico

Boca Clinical Trials Mexico SC
Puebla, Mexico

Centro de Estudios Clínicos de Querétaro (CECLIQ)
Querétaro, Mexico

PanAmerican Clinical Research - Querétaro - Avenida Antea
Querétaro, Mexico

Centro de Atención e Investigación Cardiovascular del Potosí
San Luis Potosí, Mexico

Instituto Veracruzano en Investigación Clínica S.C.
Veracruz, Mexico

FAICIC S. de R.L. de C.V.
Veracruz, Mexico

Arké SMO S.A de C.V
Veracruz, Mexico

Ziekenhuis Bethesda
Hoogeveen, Drenthe, Netherlands

Emotional Brain FlevoResearch
Almere, Flevoland, Netherlands

Medische Centrum Leeuwarden
Leeuwarden, Fryslân, Netherlands

Gelre Ziekenhuis
Apeldoorn, Gelderland, Netherlands

Ziekenhuis Gelderse Vallei
Ede, Gelderland, Netherlands

Radboudumc
Nijmegen, Gelderland, Netherlands

Ziekenhuis Rivierenland
Tiel, Gelderland, Netherlands

Atrium-Orbis - Zuyderland Medisch Centrum Heerlen
Heerlen, Limburg, Netherlands

VieCuri Medisch Centrum, locatie Venlo
Venlo, Limburg, Netherlands

Amphia Ziekenhuis, locatie Breda Molengracht
Breda, Noord-Brabant, Netherlands

Catharina Ziekenhuis
Eindhoven, Noord-Brabant, Netherlands

Bravis Ziekenhuis, locatie Roosendaal
Roosendaal, Noord-Brabant, Netherlands

Noordwest Ziekenhuisgroep
Alkmaar, Noord-Holland, Netherlands

OLVG Oost
Amsterdam, Noord-Holland, Netherlands

Amsterdam UMC, locatie AMC
Amsterdam, Noord-Holland, Netherlands

Rode Kruis Ziekenhuis
Beverwijk, Noord-Holland, Netherlands

Spaarne Gasthuis, Haarlem Zuid
Haarlem, Noord-Holland, Netherlands

Medisch Spectrum Twente
Enschede, Overijssel, Netherlands

Isala, locatie Zwolle
Zwolle, Overijssel, Netherlands

Meander Medisch Centrum
Amersfoort, Utrecht, Netherlands

Het Van Weel-Bethesda Ziekenhuis - Ziekenhuis Dirksland
Dirksland, Zuid-Holland, Netherlands

Albert Schweitzer Ziekenhuis, locatie Dordwijk
Dordrecht, Zuid-Holland, Netherlands

Franciscus Gasthuis & Vlietland, Locatie Gasthuis
Rotterdam, Zuid-Holland, Netherlands

Medisch Centrum Thomsonplein
The Hague, Zuid-Holland, Netherlands

Huisartsenpraktijk Broekman
Zwijndrecht, Zuid-Holland, Netherlands

Huisartsenpraktijk Disha
Den Haag, Netherlands

Universitair Medisch Centrum Utrecht
Utrecht, Netherlands

Dokters van Nederhoven
Zwijndrecht, Netherlands

Aotearoa Clinical Trials - Whangarei
Whangarei, Northland, New Zealand

Aotearoa Clinical Trials
Auckland, New Zealand

Centro Endocrinológico Farfán
Arequipa, Ariqipa, Peru

Hospital Alberto Sabogal Sologuren
Bellavista, Lima, Peru

Hospital Nacional Adolfo Guevara Velasco
Cusco, Qusqu, Peru

Clínica Javier Prado
Lima, Peru

Clínica El Golf
Lima, Peru

Hospital Cayetano Heredia
Lima, Peru

NZOZ Centurm Medyczne SERAFIN-MED
Zarow, Dolnośląskie, Poland

NZOZ Centrum Medyczne KERmed
Bydgoszcz, Kujawsko-pomorskie, Poland

Centrum Medyczne INTERCOR Sp. z o.o.
Bydgoszcz, Kujawsko-pomorskie, Poland

CenterMed Lublin NZOZ
Lublin, Lubelskie, Poland

Ekamed
Lublin, Lubelskie, Poland

Balsam Medica
Warsaw, Mazowieckie, Poland

Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe
Chrzanow, Małopolskie, Poland

Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET
Krakow, Małopolskie, Poland

Centrum Szybkiej Diagnostyki Kardiologicznej "Kardiomed" M. Żabówka E. Żabówka
Tarnow, Małopolskie, Poland

EndoPractica
Opole, Opolskie, Poland

Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu
Przemysl, Podkarpackie, Poland

KLIMED Marek Klimkiewicz
Bialystok, Podlaskie, Poland

Uniwersyteckie Centrum Kliniczne
Gdańsk, Pomorskie, Poland

Centrum Kliniczno-Badawcze
Elblag, Warmińsko-mazurskie, Poland

Poliklinika Kardiologiczna Serce
Leszno, Wielkopolskie, Poland

Centrum Zdrowia Metabolicznego Pawel Bogdanski
Poznań, Wielkopolskie, Poland

Pro Salus Centrum Medyczne
Lodz, Łódzkie, Poland

SPZOZ Uniwersytecki Szpital Kliniczny Im. Wojskowej Akademii Medycznej UM W Łodzi Centralny Szpital Wetera -T
Łódź, Łódzkie, Poland

Polsko-Amerykańskie Kliniki Serca II Oddział Kardiologiczny
Bielsko-Biala, Śląskie, Poland

Diab Serwis Popenda Spółka Jawna
Chorzow, Śląskie, Poland

Polsko-Amerykańskie Kliniki Serca
Tychy, Śląskie, Poland

Advanced Clinical Research, LLC
Bayamón, Puerto Rico

Clinical Research Management Group Inc
Ponce, Puerto Rico

GCM Medical Group, PSC - Hato Rey Site
San Juan, Puerto Rico

C.M.D.T.A. Neomed
Brasov, Brașov, Romania

Nicodiab
Bucharest, București, Romania

Hightech Medical Services SRL-Centrul pentru Studiul Metabolismului
Bucharest, București, Romania

Centrul Medical NutriLife
Bucharest, București, Romania

Lotus-Med Tunari
Bucharest, București, Romania

Centrul Medical Endocrinologie si Diabet Dr. Paveliu
Bucharest, București, Romania

Spitalul Clinic Județean de Urgență
Craiova, Dolj, Romania

Private Practice - Dr. Mercea Corina Delia
Baia Mare, Maramureș, Romania

CMI DNBM Dr. Pop Lavinia
Baia Mare, Maramureș, Romania

SC Dentosim Queen SRL - Centrul Medical Diamed
Târgu Mureș, Mureș, Romania

Centrul Medical Mediab
Târgu-Mureș, Mureș, Romania

Mediab S.R.L.
Târgu-Mureș, Mureș, Romania

Cabinet Medical Dr.Geru
Timisoara, Timiș, Romania

Centrul Medical Medicalis
Timisoara, Timiș, Romania

Institutul de Boli Cardiovasculare Timișoara
Timișoara, Timiș, Romania

Milena Sante
Galați, Romania

Diamed Obesity
Galați, Romania

Centrul Medical Consultmed
Iași, Romania

Cardiomed Iași
Iași, Romania

Clinica Korall
Satu Mare, Romania

Policlinica Astra Sibiu
Sibiu, Romania

IN-DIA
Lucenec, Banskobystrický Kraj, Slovakia

Nemocnica s poliklinikou Lucenec
Lucenec, Banskobystrický Kraj, Slovakia

MUDr. Judita Gondova
Poltar, Banskobystrický Kraj, Slovakia

ENRIN, s.r.o.
Rimavská Sobota, Banskobystrický Kraj, Slovakia

Cliniq s.r.o.
Bratislava, Bratislavský Kraj, Slovakia

Sin Azucar
Malacky, Bratislavský Kraj, Slovakia

Tatratrial s.r.o.
Rožňava, Košický Kraj, Slovakia

Areteus s.r.o.
Trebisov, Košický Kraj, Slovakia

Fakultná nemocnica Nitra
Nitra, Nitriansky Kraj, Slovakia

FUNKYSTUFF s.r.o.
Nove Zamky, Nitriansky Kraj, Slovakia

MEDIKALS
Piešťany, Trnavský Kraj, Slovakia

ENDIAMED s.r.o
Dolny Kubin, Žilinský Kraj, Slovakia

JM-Interna s.r.o
Dolny Kubin, Žilinský Kraj, Slovakia

NEDÚ - Národný endokrinologický a diabetologický ústav n.o.
Lubochna, Žilinský Kraj, Slovakia

AMBORA s.r.o. Interna ambulancia
Martin, Žilinský Kraj, Slovakia

MediPrax, s.r.o.
Trstena, Žilinský Kraj, Slovakia

B-Medical, s.r.o.
Tvrdošín, Žilinský Kraj, Slovakia

IRIDIA
Vrutky, Žilinský Kraj, Slovakia

CHUAC-Complejo Hospitalario Universitario A Coruña
A Coruña, A Coruña [La Coruña], Spain

Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval
Ferrol, A Coruña [La Coruña], Spain

Centro Periférico de Especialidades Bola Azul
Almeria, Almería, Spain

Hospital Universitario Virgen de la Victoria
Malaga, Andalucía, Spain

Hospital Quiron Infanta Luisa
Sevilla, Andalucía, Spain

Hospital Universitario Central de Asturias
Oviedo, Asturias, Principado De, Spain

Clínica Juaneda
Palma de Mallorca, Balears [Baleares], Spain

Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [Barcelona], Spain

Hospital Universitario Marqués de Valdecilla
Santander, Cantabria, Spain

Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, Madrid, Spain

Vithas Hospital Sevilla
Seville, Sevilla, Spain

Hospital Universitario de La Ribera
Alzira, Valenciana, Comunitat, Spain

Hospital Universitario Doctor Peset
Valencia, València, Spain

Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
Sevilla, Spain

Bursa Yüksek İhtisas Eğitim Ve Araştırma Hastanesi
Yıldırım, Bursa, Turkey

Eskisehir Osmangazi University
Eskisehir, Eskişehir, Turkey

Istanbul Universitesi Cerrahpasa
Istanbul- Fatih, İstanbul, Turkey

Ege Universitesi Hastanesi
Bornova, İzmir, Turkey

Kocaeli Üniversitesi
Izmit, Kocaeli, Turkey

Adana Sehir Egitim ve Arastirma Hastanesi
Adana, Turkey

Afyon Kocatepe Üniversitesi Tıp Fakültesi
Afyonkarahisar, Turkey

Ankara Bilkent Şehir Hastanesi
Ankara, Turkey

Hacettepe Universite Hastaneleri
Ankara, Turkey

Akdeniz Universitesi Hastanesi
Antalya, Turkey

T.C. Saglik Bakanligi - Hitit Universitesi Corum Egitim ve Arastirma Hastanesi
Corum, Turkey

Trakya University Medical Faculty Hospital
Edirne, Turkey

Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
Gaziantep, Turkey

Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi
Istanbul, Turkey

Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştirma Hastanesi
Istanbul, Turkey

Erciyes Universitesi Tıp Fakultesi Hastaneleri
Kayseri, Turkey

Kocaeli Üniversitesi
Kocaeli, Turkey

Necmettin Erbakan University Meram Medical Faculty ; Internal Diseases
Konya, Turkey

T.C. Saglik Bakanligi - Dumlupinar Universitesi Kutahya Evliya Celebi Egitim ve Arastirma Hastanesi
Kütahya, Turkey

Mersin University
Mersin, Turkey

Cumhuriyet Universitesi
Sivas, Turkey

Chernivetsky Oblasny Endokrynologichny Centr, Oblasna Komunalna Ustanova
Chernivtsi, Chernihivska Oblast, Ukraine

Vise Clinic
Ivano-Frankivsk, Ivano-Frankivska Oblast, Ukraine

Clinical Diagnostic Center
Ivano-Frankivsk, Ivano-Frankivska Oblast, Ukraine

Edelweiss Medics
Kyiv, Kyivska Oblast, Ukraine

Medbud Clinic
Kyiv, Kyivska Oblast, Ukraine

Institute of Endocrinology and Metabolism named after Komissarenko
Kiev, Kyiv, Ukraine

Lviv City Clinical Hospital #4
Lviv, Lvivska Oblast, Ukraine

Medical center Pulse in Vinnitsi
Vinnytsia, Vinnytska Oblast, Ukraine

Limited liability company "Medical center Health Clinic"
Vinnytsia, Vinnytska Oblast, Ukraine

Vinnytsia Regional Clinical Endocrinology Dispensary
Vinnytsia, Vinnytska Oblast, Ukraine

Communal Enterprise "Hospital #1" of Zhytomyr City Council
Zhytomyr, Zhytomyrska Oblast, Ukraine

Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal"
Kyiv, Ukraine

ARTEM
Kyiv, Ukraine

Center of Family Medicine Plus
Kyiv, Ukraine

Branch "Center of Endocrinological Health" of "Lviv Regional Clinical Diagnostic Center"
Lviv, Ukraine

Aberdeen Royal Infirmary
Aberdeen, Aberdeen City, United Kingdom

Newquay Health Centre
Newquay, Cornwall, United Kingdom

Homecroft Surgery
Redruth, Cornwall, United Kingdom

Rame Group Practice
Torpoint, Cornwall, United Kingdom

Royal London Hospital
London, England, United Kingdom

Hull Royal Infirmary
Hull, Kingston Upon Hull, United Kingdom

Musgrove Park Hospital
Taunton, Somerset, United Kingdom

Ipswich Hospital
Ipswich, Suffolk, United Kingdom

Swansea University
Swansea, Swansea [Abertawe Gb-ata], United Kingdom

FutureMeds - Liverpool
Bromborough, Wirral, United Kingdom

FutureMeds - Birmingham
Birmingham, United Kingdom

University Hospital Coventry & Warwickshire
Coventry, United Kingdom

Contacts

There may be multiple sites in this clinical trial. 1-877-CTLILLY (1-877-285-4559) or
1-317-615-4559
clinical_inquiry_hub@lilly.com

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST), Study Director
Eli Lilly and Company

Eli Lilly and Company
NCT Number
Keywords
Cardiovascular disease
kidney disease
Major Adverse Cardiovascular Events (MACE)
Renal Outcomes
Cardiovascular Risk Reduction
Kidney Disease Progression
Cardiometabolic Risk Factors
Cardiovascular Outcomes
Kidney Outcomes
Type 2 diabetes
Heart disease
Coronary Artery Disease
Cerebrovascular Disease
Peripheral Arterial Disease
Nonfatal Myocardial Infarction (MI)
Nonfatal Stroke
Cardiovascular (CV) Death
Hospitalization or Urgent Visit Due to Heart Failure (HF)
Renal Death
End Stage Kidney Disease (ESKD)
MeSH Terms
Kidney Diseases
Renal Insufficiency, Chronic
Cardiovascular Diseases
Atherosclerosis