The goal of this clinical trial is to test whether the intervention of probioticssupplement can improve symptoms of long covid syndrome.Participants will be given probiotics or placebo capsules for two month. Symptomquestionnaires, cognitive function, eeg and fecal sample are recorded/collected beforeand after the supplement.Researchers will compare the probiotic group and the placebo to see if probioticsupplement really make differences.
After the pandemic of covid-19, people found out that not only does it cause acute
respiratory system symptoms, but it also affect many other systems even long after the
acute symptoms have resolved, which is named the Long Covid Syndrome. Studies have shown
that the gut microbiota of those suffering from long covid syndrome differ from that of
healthy people and those who recovered from covid without getting long covid syndrome,
which implied the possibility of probiotic supplement being an effective treatment to
long covid. This double-blind parallel randomized control trail plans to supply
participants with probiotics or placebo fortwo months. Symptom questionnaires, cognitive
function, eeg and fecal sample will be recorded/collected before and after the
supplement. Researchers will compare the two groups to see if they differ in the above
measure and to see if the differences in symptoms and cognitive functions change
correlate with gut microbiota change and fecal metabolite change.
Dietary Supplement: Lactobacillus paracasei PS23
2 caps daily use
Dietary Supplement: microcrystalline cellulose
2 caps daily use
Inclusion Criteria:
- 20 to 80 year old
- had been infected by SARS-CoV-2
- Stable vital signs
- Have brain fog conplaint
- MoCA<30 at baseline
Exclusion Criteria:
- refuse to join the study or refuse to sign the Informed Consent Form
- have other neurological disease that may affect cognitive function, such as
Parkinson disease, Seizure, etc.
- have other gastrointestinal disease that may affect cognitive function, including
tumors.
- severe hearing loss or visual loss that may hinder cognitive function tests
- Taken anti-seizure drug in 7 days.
- Already taking probiotics supplement regularly
- Taken antibiotics in two weeks
- taking stool softener or laxative regularly
- have valvular heart disease
- have congenital or acquired immunodeficiency or is under iimmunosuppressant therapy
- Pregnant or plans to be pregnant
- BMI>30
- Have been performed severe gastrointestinal surgery(s)
- Severe liver, kidney, cardiovascular, hematologic or metabolic disorder
- In critical condition
Not Provided
Chieh Lee, Medical student
+886-0971839369
jason.jay.lee@gmail.com
Ching-Liang Lu, MD, PhD
0971839369
cllu@vghtpe.gov.tw
Not Provided