Official Title
Determination of SARS-Cov-2 Virus in Central Nervous System
Brief Summary

Coronavirus disease 2019 (COVID-19) is a highly infectious pandemic disease caused bySARS-CoV-2 virus. Central Nervous System (CNS) complications associated with COVID-19might be secondary sequelae due to exuberant systemic innate-mediated hyper-inflammation,which may impair neurovascular endothelial function, disrupt blood brain barrier (BBB),activates CNS innate immune signaling pathways, and induces parainfectious autoimmunity,potentially contributing to the CNS manifestations. Although the predominant clinicalmanifestation of SARS-CoV-2 is characterized by dyspnea, unremitting fever and hypoxemicrespiratory failure, neurologic manifestations do occur in most hospitalized SARS-CoV-2patients and include non-specific encephalopathy, psychosis, meningitis/encephalitis,myelitis, cerebrovascular events, Guillain-Barre' syndrome, and cranial or peripheralneuropathies, such as anosmia and ageusia. To date, data about primary CNS involvementdue to neurotropism and direct neuroinvasion are still lacking.

Detailed Description

Determination of SARS-CoV-2 presence in central nervous system

Recruiting
COVID-19 Testing
CNS Disease
CNS Infection

Diagnostic Test: Determination of SARS-CoV2 presence in CNS

Brain tissue sampling

Eligibility Criteria

Inclusion Criteria:

- Adult patients

- Patients candidate for CNS surgery

- Patients who have been tested for nasopharyngeal swab for SARS-CoV-2

- Patients who have been tested for serology test for anti SARS-CoV-2 immunoglobulinG
(IgG) and immunoglobulinM (IgM) antibodies

- Patients able to sign informed consent

Exclusion Criteria:

- Patients not meeting inclusion criteria

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
Italy
Locations

IRCCS San Raffaele Scientific Institute
Milan, Italy

Investigator: Laura Sincinelli
Contact: 003926435568
sincinelli.laura@hsr.it

Contacts

Laura Sincinelli
00390226435568
sincinelli.laura@hsr.it

Pietro Mortini, MD, Prof., Principal Investigator
IRCCS San Raffaele Scientific Institute

IRCCS San Raffaele
NCT Number
Keywords
SARS-CoV-2
CNS infection
Coronavirus
brain
MeSH Terms
COVID-19
Central Nervous System Infections
Central Nervous System Diseases