Coronavirus disease 2019 (COVID-19) is a highly infectious pandemic disease caused bySARS-CoV-2 virus. Central Nervous System (CNS) complications associated with COVID-19might be secondary sequelae due to exuberant systemic innate-mediated hyper-inflammation,which may impair neurovascular endothelial function, disrupt blood brain barrier (BBB),activates CNS innate immune signaling pathways, and induces parainfectious autoimmunity,potentially contributing to the CNS manifestations. Although the predominant clinicalmanifestation of SARS-CoV-2 is characterized by dyspnea, unremitting fever and hypoxemicrespiratory failure, neurologic manifestations do occur in most hospitalized SARS-CoV-2patients and include non-specific encephalopathy, psychosis, meningitis/encephalitis,myelitis, cerebrovascular events, Guillain-Barre' syndrome, and cranial or peripheralneuropathies, such as anosmia and ageusia. To date, data about primary CNS involvementdue to neurotropism and direct neuroinvasion are still lacking.