Inclusion Criteria:

- Age 18-75 years, both sexes.

- Patients with histologically confirmed post-surgical recurrent/metastatic or locally
advanced inoperable surgically resectable squamous cell carcinoma of the head and
neck with measurable lesions (spiral CT scan ≥ 10 mm, meeting RECIST 1.1 criteria).

- Have received at least 1 cycle of prior PD-1 immunotherapy with imaging confirmation
of progression or clinician determination of no continued benefit from treatment;
provided that this is completed at least 4 weeks prior to the first dose of study
drug and all associated toxic events have returned to normal or grade I or less as
defined by CTCAE 4.03 classification.

- HPV viral testing determined to be negative, using the IHC method.

- Availability of tumor tissue (paraffin specimens less than 2 years old or fresh
tumor tissue) for detection of PD-L1 and CDK4-related genes.

- ECOG score of 0 or 1.

- Expected survival of ≥ 12 weeks.

- Normal major organ function within 2 weeks prior to treatment, i.e., meeting the
following criteria：Bone marrow function: hemoglobin ≥ 100 g/L without transfusion or
colony-stimulating factor support therapy, white blood cell count ≥ 4.0*10^9/L or
neutrophil count ≥ 2.0*10^9/L, and platelet count ≥ 100*10^9/L; Liver: serum total
bilirubin level ≤ 1.5 times the upper limit of normal, aspartate aminotransferase
(AST) and alanine aminotransferase (ALT) ≤ 1.5 times the upper limit of normal;
Renal: blood creatinine level below 1.5 times the upper limit of normal or
creatinine clearance ≥ 60 ml/min and urea nitrogen ≤ 200 mg/L; Urine protein <+, or
if urine protein + then total 24-hour protein must be <500mg; Blood glucose: within
normal range and/or with diabetes in treatment but under stable glycemic control;
Pulmonary function: baseline FEV1 of at least 2L; if baseline FEV1 <2L then FEV1
>800ml expected post-surgery as assessed by a surgical specialist; Cardiac function:
no myocardial infarction within 1 year; no unstable angina; no symptomatic severe
arrhythmias; no cardiac insufficiency.

Exclusion Criteria:

- Patients previously treated with cetuximab or other anti-EGFR monoclonal antibodies
or small molecule tyrosine kinase inhibitors.

- Patients who are currently receiving antineoplastic therapy.

- Patients who have participated or are participating in a clinical trial of another
drug/therapy within 4 weeks prior to the first dose of the study drug.

- Patients who have received hematopoietic stimulating factors, such as granulocyte
colony-stimulating factor (G-CSF), erythropoietin, etc., within 1 week prior to the
first dose of the study drug.

- Positive HIV antibody or syphilis spirochete antibody test results.

- Patients with active hepatitis B or C: If positive for HBsAg or HBcAb, additional
HBV DNA testing (results above the upper limit of the normal range). If HCV antibody
test result is positive, add HCV RNA test (result above the upper limit of the
normal range).

- Known hypersensitivity to recombinant humanized EGFR monoclonal antibody drugs and
their components.

- Massive pleural or ascites fluid with clinical symptoms and requiring symptomatic
management.

- Active lung disease (interstitial pneumonia, pneumonia, obstructive lung disease,
asthma) or a history of active tuberculosis.

- Has any uncontrollable clinical problem, including but not limited to: Persistent or
active (severe) infection; Poorly controlled diabetes mellitus; Cardiac disease
(Class III/IV congestive heart failure or heart block as defined by the New York
Heart Association); Deep vein thrombosis or pulmonary embolism; myocardial
infarction; severe or unstable arrhythmia or angina; percutaneous coronary
intervention, acute coronary syndrome, coronary artery bypass grafting;
cerebrovascular accident, transient ischemic attack, cerebral embolism within 6
months prior to first dose.

- Previous stem cell transplantation or organ transplantation.

- Those with a history of psychotropic substance abuse and unable to abstain or a
history of psychiatric disorders.

- Other serious, acute or chronic medical conditions or abnormalities in laboratory
tests that, in the judgment of the investigator, may increase the risk associated
with study participation or may interfere with the interpretation of study results.

- Patients who, in the judgment of the investigator, have poor compliance or other
conditions that make them unsuitable for participation in this trial.

- Patients with a history of other malignancies within five years.