To investigate the incidence of SARS-CoV-2 infections after vaccination, to monitor thedevelopment of SARS-CoV-2 antibody levels after vaccination and to compare this inrelation to both previous health & disease, previous antibody responses and in relationto future disease occurring after vaccination.
The purpose of the study is to analyze the effect of and possible side effects of
SARS-CoV2 vaccinations in the cohort study where data on sick leave, SARS-Cov2 infections
and SARS-CoV2 antibody levels are well documented even before vaccination.
The main outcome measures are the presence of SARS-CoV-2 (ongoing infection) and the
presence of antibodies to SARS-CoV-2.
For the vaccination effect, the factors that are primarily associated with protection
against infection are analyzed, such as age, sex, workplace, antibody response to
SARS-CoV-2 and vaccination date.
The analyzes are planned to be performed with multivariate logistic regression with
Relative Risk as the outcome measure.
Data from the analysis of virus antibodies are planned to be performed divided into
whether low, medium or high levels of antibodies occur, with the same analysis for
possible association with the factors listed above.
Diagnostic Test: SARS-CoV2 antibody measurement
Blood samples for serology, collected immediately prior to and five to ten weeks after
vaccination against SARS-CoV2, to be analyzed for the presence of SARS-CoV-2 antibodies.
Inclusion Criteria:
- Study participant who agreed to be included in the study "Studies of ongoing and
completed SARS-CoV-2 infection (which causes COVID-19) within the healthcare in
Stockholm County".
- Study participant who has received or will receive vaccine against Covid-19 and who
gives new written consent to the study "Studies of ongoing and completed SARS-CoV-2
infection (which causes COVID-19) within the healthcare in Stockholm County, with
regard to vaccinations".
Exclusion Criteria:
- those who have not given informed consent to participate in the study In this study,
no initiative is taken for vaccination. The vaccinations are carried out by the
healthcare system and of course follow the established exclusion and inclusion
criteria for the approved vaccines. All persons who have received the vaccine and
who give written consent are eligible to be included in the study.
Karolinska University Hospital
Stockholm, Sweden
Joakim Dillner, MD, PhD, Principal Investigator
Karolinska Institutet