Monoclonal gammopathy (MG) is an asymptomatic pre-cancerous clonal proliferation of
plasma cells. The onset of this disease is concealed, usually discovered by chance by
patients who undergo protein electrophoresis to detect monoclonal gamma globulin (M
protein) due to various clinical symptoms and disease evaluations. Due to the insidious
onset of monoclonal immunoglobulin, involving multiple organs, and the non-specific
clinical symptoms, it is more prone to misdiagnosis. This study hypothesized that among
patients who first came to the hospital for treatment, some patients had elevated serum
monoclonal immunoglobulin levels but were not initially diagnosed with hematology
department, but instead sought medical attention from other departments due to other
symptoms. In this study，by using a highly sensitive serum M protein detection method
based on the MALDI-TOF MS platform, serum monoclonal immunoglobul (M protein) in
detection was performed on the visiting patients to explore the positive rate of serum M
protein and its distribution in different departments，and to explore the correlation
analysis between the relative concentration of serum M protein based on the above highly
sensitive methods and clinical indicators.