Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) 2 infection and the associatedcoronavirus disease 2019 (COVID-19) are the most recent international health threatchallenging our ability to protect populations, to avoid severe outcomes and tounderstand both the population dynamics of this new condition and the breath ofindividual responses. Gathering information on the clinical course of the disease and therisk of transmission is essential to design effective therapeutic solutions andpreventive measures. The aim of the study proposed, to be carried out at UniversityHospital Center of "São João" (CHUSJ), is to recruit and follow-up a cohort of patientsdiagnosed with SARS-CoV-2 infection, to evaluate the clinical course of SARS-CoV-2infection and COVID-19 cases, to identify prognostic factors and to measure the risk ofreinfection. Additionally, researchers intend to characterize the patients and householdcontacts to describe the dynamics of infection, to calculate household infection attackrate, and to perform the genetic sequencing of SARS-CoV-2 to understand determinants ofdisease course (namely long-term effects) and risk of household transmission. A sample ofparticipants, identified during the process of evaluation of symptomatic individuals, atthe same institution, and negative for SARS-CoV-2 will be selected as negative controls.Participants will be consecutively recruited and the study is expected to enroll patientsas long as the pandemic remains. Information will be gathered based on clinicalindividual charts, hospital data-bases (example: for administrative data) and individualcomputer assisted interviews to be performed at pre-defined intervals (3, 12 and 24months) or according to clinical needs.The project was approved by the local Ethical Committee and the Data Protection relevantauthorities.