Official Title
COVID-19 Risk Stratification
Brief Summary

We seek to derive and validate a clinically useful risk score for patients with Coronavirus Disease 2019 to aide clinicians in the safe discharge of patients.

Detailed Description

We a-priori plan the following analysis:

1. Derivation and Retrospective Validation.

- Select all adult patients with a positive reverse transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 beginning March 1, 2020 until approximately 1000 patients are included.

- Use 75% of this cohort to develop a simple risk-score that prognosticates a patient's suitability for discharge (no supplemental oxygen, no intensive care unit, and no death). Use multivariable logistic regression with forward selection informed by clinical judgement to choose variables a priori that emphasizes readily available data and easy calculation for use at the point of care.

- Use 25% of this cohort to retrospectively validate the risk-score.

2. Prospective Validation.

- Select all adult patients with a positive reverse transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 as soon as the derivation cohort in step 1 is assembled. Include approximately 250 patients.

- Use this sample to prospectively validate the risk-score developed in part 1.

Recruiting
Coronavirus
Coronavirus Sars-Associated as Cause of Disease Classified Elsewhere
Eligibility Criteria

Inclusion Criteria:

- Positive reverse transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2

- Age 18 and older

Exclusion Criteria:

- None

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years
Countries
United States
Locations

Brigham and Women's Hospital
Boston, Massachusetts, 02115

Recruiting

Investigator: David M Levine, MD MPH MA
Contact: 617-732-7063
dmlevine@bwh.harvard.edu

Investigator: David M Levine, MD MPH MA

Contacts

David Levine, MD
617-732-7063
dmlevine@bwh.harvard.edu

Brigham and Women's Hospital
NCT Number
MeSH Terms
Coronavirus Infections
Severe Acute Respiratory Syndrome