During the COVID-19 pandemic several countries have seen a high risk of transmission for health care personnel, with some countries having as many 20-25% of nurses and doctors either infected or showing symptoms of COVID-19. In this prospective cohort study, we will systematically screen all hospital staff in the Capital Region of Denmark for IgM and IgG antibodies against SARS-CoV-2 using a point of care tests and an Elisa kit. Testing will be offered 3 times: In April 2020, Maj 2020 and September 2020. All participants will submit a questionnaire regarding exposures, risk factors and symptoms of COVID-19 in relation to each testing. Follow-up will be through electronic patient records and national registries. We will compare the group of health care personnel with data from a control group of healthy volunteer blood donors from the Danish Blood Donor Study. The aim of the study is to investigate the proportion of hospital staff with SARS-CoV-2 antibodies during the study period compared to a control group representing the Danish population. We will compare the test characteristics of the two methods of testing, a point of care test and Elisa. Further, we will investigate the extent to which prior immunization or infection is protective for future infection with COVID-19.
Diagnostic Test: IgM and IgG diagnostic kits to SARS-CoV-2
Diagnostic kits for IgM/IgG antibodies to SARS-CoV-2
Diagnostic Test: Elisa-test for IgM and IgG to SARS-CoV-2
Elisa-test for IgM and IgG to SARS-CoV-2
Inclusion Criteria: - >18 years old - Consent to participation - Employed at a Hospital in the Capitial Region of Denmark
Exclusion Criteria: - None
Kasper Iversen, Prof.
Principal Investigator
Herlev-Gentofte Hospital
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Henning Bundgaard, Prof.
Principal Investigator
Rigshospitalet, Denmark
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Henrik Ullum, Prof.
Principal Investigator
Rigshospitalet, Denmark
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Thomas Benfield, Prof.
Principal Investigator
Hvidovre University Hospital
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Susanne Dam Poulsen, Prof.
Principal Investigator
Rigshospitalet, Denmark
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Jørgen Rungby, Prof.
Principal Investigator
Bispebjerg Hospital
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Fredrik Folke, Associate prof.
Principal Investigator
Akutberedskabet
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Thea Kølsen Fischer
Principal Investigator
Nordsjællands Hospital
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Ove Andersen, Prof.
Principal Investigator
Hvidovre University Hospital
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Ida Hageman
Principal Investigator
Mental Health Services in the Capital Region, Denmark