Official Title
COVID-19: Investigation of Transmission and Immunisation Among Hospital Staff
Brief Summary

During the COVID-19 pandemic several countries have seen a high risk of transmission for health care personnel, with some countries having as many 20-25% of nurses and doctors either infected or showing symptoms of COVID-19. In this prospective cohort study, we will systematically screen all hospital staff in the Capital Region of Denmark for IgM and IgG antibodies against SARS-CoV-2 using a point of care tests and an Elisa kit. Testing will be offered 3 times: In April 2020, Maj 2020 and September 2020. All participants will submit a questionnaire regarding exposures, risk factors and symptoms of COVID-19 in relation to each testing. Follow-up will be through electronic patient records and national registries. We will compare the group of health care personnel with data from a control group of healthy volunteer blood donors from the Danish Blood Donor Study. The aim of the study is to investigate the proportion of hospital staff with SARS-CoV-2 antibodies during the study period compared to a control group representing the Danish population. We will compare the test characteristics of the two methods of testing, a point of care test and Elisa. Further, we will investigate the extent to which prior immunization or infection is protective for future infection with COVID-19.

Enrolling by invitation
COVID

Diagnostic Test: IgM and IgG diagnostic kits to SARS-CoV-2
Diagnostic kits for IgM/IgG antibodies to SARS-CoV-2
Healthy volunteer blood donors
Hospital Staff in the Capital Region of Denmark

Diagnostic Test: Elisa-test for IgM and IgG to SARS-CoV-2
Elisa-test for IgM and IgG to SARS-CoV-2
Healthy volunteer blood donors
Hospital Staff in the Capital Region of Denmark

Eligibility Criteria

Inclusion Criteria: - >18 years old - Consent to participation - Employed at a Hospital in the Capitial Region of Denmark

Exclusion Criteria: - None

Eligibility Gender
All
Countries
Denmark

Kasper Iversen, Prof.
Principal Investigator
Herlev-Gentofte Hospital

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Henning Bundgaard, Prof.
Principal Investigator
Rigshospitalet, Denmark

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Henrik Ullum, Prof.
Principal Investigator
Rigshospitalet, Denmark

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Thomas Benfield, Prof.
Principal Investigator
Hvidovre University Hospital

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Susanne Dam Poulsen, Prof.
Principal Investigator
Rigshospitalet, Denmark

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Jørgen Rungby, Prof.
Principal Investigator
Bispebjerg Hospital

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Fredrik Folke, Associate prof.
Principal Investigator
Akutberedskabet

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Thea Kølsen Fischer
Principal Investigator
Nordsjællands Hospital

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Ove Andersen, Prof.
Principal Investigator
Hvidovre University Hospital

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Ida Hageman
Principal Investigator
Mental Health Services in the Capital Region, Denmark

Herlev Hospital
Nordsjaellands Hospital
Hvidovre University Hospital
Rigshospitalet, Denmark
Mental Health Services in the Capital Region, Denmark
University Hospital Bispebjerg and Frederiksberg
NCT Number
MeSH Terms
Immunoglobulin G
Immunoglobulin M