Official Title
A Multicenter, Prospective Study of COVID-19 Using Real-Time Syndromic Surveillance, Scheduled At-home Serologic Testing, and Electronic Health Records
Brief Summary

The purpose of this research is to collect information about the North Carolina community's coronavirus exposures, symptoms, and health care visits due to the virus. Participation in this study will involve completing a daily questionnaire which covers participants coronavirus illness history or symptoms, health care seeking behaviors and treatments, contact with other sick people, and for health care workers, their use of personal protective equipment.

Detailed Description

Investigators will conduct a prospective, cohort study for SARS-CoV-2 infections among

clients and health care workers of Wake Forest Baptist Health (WFBH). Investigators will

conduct real-time syndromic respiratory disease surveillance and, for SARS-CoV-2 infections,

calculate baseline seroprevalence and seroconversion rates, hazard risks from close contacts,

estimate efficacy of personal protective equipment, and assess sequelae incidence.

Investigators will utilize the COVID-19 Therapeutic Learning System, an Oracle developed

self-reporting data collection system that can be easily modified to address these specific

questions. Over the course of the study, volunteers will report daily exposures, risk

reduction behaviors, and symptoms through a secure app on their smartphone, tablet, or

computer. In addition to daily syndromic surveillance, at baseline and once every month after

that we will use a serologic IgM/G test kit to identify infections and reinfections in

volunteers and send results to the Oracle developed database. The areas covered by this study

are experiencing community spread of COVID-19 but are early enough in the epidemic to capture

potentially a significant number of seroconversions over the 12 months of the study. This

surveillance model will be expanded to include the clients and health workers of other

medical agencies in North Carolina and in other states.

Eligibility Criteria

Inclusion Criteria: - All clients and health care worker of WFBH are eligible for enrollment.

Exclusion Criteria: - Health care workers who do not receive medical services through WFBH will not be enrolled.

Eligibility Gender
United States

Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, 27157



Wake Forest Baptist Medical Center

John W Sanders, MD, MPH&TM
Principal Investigator
Wake Forest University Health Sciences

Wake Forest University Health Sciences
NCT Number
MeSH Terms
Coronavirus Infections