Inclusion Criteria: - Adults age 40 years and older - with suspected or confirmed acute COVID-19 infection. Acute COVID-19 infection is suspected in the presence of a fever and at least one symptom of respiratory disease e.g. cough, difficulty breathing, signs of hypoxia. The clinician may suspect COVID-19 infection if i) the patient lives in or has recently travelled to an area with COVID-19 transmission; ii) the patient had recent contact with a confirmed or probable COVID-19 case, or iii) no alternative diagnosis fully explains the clinical presentation - requiring hospitalisation

Exclusion Criteria: - Women known to be pregnant - Patients hospitalised without symptoms of acute COVID-19 infection should not be recruited even if they test positive for COVID-19 - Patients already receiving mechanical ventilation - Patients with a definite indication or contraindication for any of the trial treatments. - Patients who are very severely frail (completely dependent and approaching end of life who typically they could not recover even from a mild illness) or terminally ill should not be recruited.