Official Title
Convalescent Plasma in the Treatment of COVID 19
Brief Summary

The purpose of this study is to collect blood from previously COVID-19 infected persons who have recovered and use it as a treatment for those who are currently sick with a severe or life-threatening COVID-19 infection.

Detailed Description

The purpose of this prospective interventional study is to gain clinical experience using
convalescent plasma transfusion administered to critically ill patients with COVID-19.

1 To study the efficacy of plasma from patients recovered from COVID-19 infection with a high
neutralizing antibody titer (NAT) as treatment for individuals who are critically ill with
COVID-19.

2. Determine if the antibodies from convalescent plasma will suppress virus load in
critically ill patients with COVID-19.

Completed
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
COVID
Coronavirus

Biological: Convalescent Plasma

treatment with 2 Units of convalescent plasma

Eligibility Criteria

Inclusion Criteria:

- All genders

- Age > 18 yrs and < 90 yrs

- Must have laboratory confirmed COVID-19

- Must provide informed consent

- Must have severe or immediately life-threatening COVID-19,

Severe disease is defined as:

- dyspnea,

- respiratory frequency ≥ 30/min,

- blood oxygen saturation ≤ 93%,

- partial pressure of arterial oxygen to fraction of inspired oxygen ratio < 300

- lung infiltrates > 50% within 24 to 48 hours

Life-threatening disease is defined as:

- respiratory failure,

- septic shock

- multiple organ dysfunction or failure

Exclusion Criteria:

- No gender exclusion

- Age < 18 yrs and > 90 yrs

- COVID-19 negative

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: 90 Years
Countries
United States
Locations

Trinity Health Of New England
Hartford, Connecticut, United States

Latha Dulipsingh, MD, Principal Investigator
Saint Francis Hospital and Medical Centerr/Trinity Health Of New England

Trinity Health Of New England
NCT Number
Keywords
SARS-CoV-1, COVID, Coronavirus, convalescent plasma, plasma
MeSH Terms
Coronavirus Infections
Severe Acute Respiratory Syndrome