Official Title
Convalescent Plasma in the Treatment of COVID 19
Brief Summary

The purpose of this study is to collect blood from previously COVID-19 infected persons who have recovered and use it as a treatment for those who are currently sick with a severe or life-threatening COVID-19 infection.

Detailed Description

The purpose of this prospective interventional study is to gain clinical experience using
convalescent plasma transfusion administered to critically ill patients with COVID-19.

1 To study the efficacy of plasma from patients recovered from COVID-19 infection with a high
neutralizing antibody titer (NAT) as treatment for individuals who are critically ill with

2. Determine if the antibodies from convalescent plasma will suppress virus load in
critically ill patients with COVID-19.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Biological: Convalescent Plasma

treatment with 2 Units of convalescent plasma

Eligibility Criteria

Inclusion Criteria:

- All genders

- Age > 18 yrs and < 90 yrs

- Must have laboratory confirmed COVID-19

- Must provide informed consent

- Must have severe or immediately life-threatening COVID-19,

Severe disease is defined as:

- dyspnea,

- respiratory frequency ≥ 30/min,

- blood oxygen saturation ≤ 93%,

- partial pressure of arterial oxygen to fraction of inspired oxygen ratio < 300

- lung infiltrates > 50% within 24 to 48 hours

Life-threatening disease is defined as:

- respiratory failure,

- septic shock

- multiple organ dysfunction or failure

Exclusion Criteria:

- No gender exclusion

- Age < 18 yrs and > 90 yrs

- COVID-19 negative

Eligibility Gender
Eligibility Age
Minimum: 18 Years ~ Maximum: 90 Years
United States

Trinity Health Of New England
Hartford, Connecticut, United States

Latha Dulipsingh, MD, Principal Investigator
Saint Francis Hospital and Medical Centerr/Trinity Health Of New England

Trinity Health Of New England
NCT Number
SARS-CoV-1, COVID, Coronavirus, convalescent plasma, plasma
MeSH Terms
Coronavirus Infections
Severe Acute Respiratory Syndrome