This prospective observational study is designed to evaluate the effects of modifiedthoracoabdominal nerve block through perichondrial approach (M-TAPA) and external obliqueintercostal (EOI) plane block on intraoperative analgesia and opioid consumption inpatients undergoing elective laparoscopic cholecystectomy. Abdominal wall blocks arewidely used to improve perioperative analgesia; however, their impact on intraoperativeopioid requirements when guided by objective nociception monitoring remains unclear.All patients will receive standardized general anesthesia. Intraoperative analgesia willbe guided using the Skin Conductance Algesimeter (SCA), which reflects sympatheticnervous system activity by measuring fluctuations in skin conductance. The SCA parameter"peaks per second (PPS)" will be used to assess nociceptive responses. Remifentanilinfusion will be titrated according to SCA values to maintain adequate analgesia. Doseadjustments will be performed at predefined intervals, and changes will be consideredvalid only if sustained for a minimum duration.Patients will receive either M-TAPA or EOI block as part of routine clinical practice.The choice of block will not be influenced by the investigators, in accordance with theobservational design of the study. Data will be collected prospectively during theintraoperative period and postoperative follow-up.The primary outcome of the study is the time-weighted average intraoperative remifentanilinfusion rate (µg/kg/min). Secondary outcomes include total intraoperative remifentanilconsumption (µg/kg), intraoperative hemodynamic parameters (heart rate and mean arterialpressure), frequency of deviations in SCA values from the target range, postoperativepain scores assessed using a numeric rating scale (NRS), time to first analgesicrequirement, and total rescue analgesic consumption.Perioperative analgesia will be standardized. All patients will receive intravenousdexketoprofen toward the end of surgery as part of routine clinical practice. Rescueanalgesia will be provided with intravenous dexketoprofen when clinically indicated.Additional outcomes include postoperative nausea and vomiting and perioperativecomplications.This study aims to provide objective data on the opioid-sparing effects of differentabdominal wall block techniques when intraoperative analgesia is guided by nociceptionmonitoring. The findings may contribute to optimizing analgesic strategies and improvingperioperative pain management in laparoscopic surgery.