The goal of this observational study is to ascertain the practice patterns and predictorsin performing lung protective ventilation as per clinical guidelines for adult patientsundergoing non-cardiac surgery in Fraser Health Authority, a large Canadian authority inthe lower mainland of British Columbia, Canada. In particular, the investigators explorechanges before/after the COVID-19 pandemic. The main questions it aims to answer are: - In this population, what is the general compliance rate to lung protective ventilation - In this population, what are the predictors of compliance before/after the COVID-19 pandemic.This is a retrospective study using linked patient data from two databases in the healthregion: the anesthesia informational management system for intraoperative data, and theelectronic medical record for perioperative data.Rationale for study:Breathing problems after surgery affect 5% to 33% of patients and can lead to seriousissues like lung infections, breathing failure, and longer hospital stays, with up to a20% risk of death within 30 days for serious cases. A proven way to reduce these risks islung protective ventilation (LPV), a technique used during surgery where the ventilatordelivers smaller breaths based on clinical guidelines and calculated using a person'sideal body weight, while applying gentle pressure to keep the lungs slightly open. Whilethis approach has been widely adopted in intensive care units over the past 20 years,it's less commonly used in operating rooms, with fewer than half of surgeries using it.Barriers include suboptimal default ventilator settings, patients at extremes of weight,and misunderstandings of LPV among clinicians. During the COVID-19 pandemic, LPV useincreased for patients with COVID-related lung problems, showing improved survival ratesin ICUs. However, it's unclear if this practice carried over to surgical patientsat-large or continued after the pandemic. Most studies on LPV during surgery have beenconducted outside Canada, where healthcare practices and education may differ from withinCanada. To address these gaps, the investigators aim to study LPV use during surgery in alarge Canadian health system, identify factors that influence its use, and examine trendsduring and after the COVID pandemic. This research will help improve patient care bypromoting the use of this effective technique in Canadian operating rooms.
This observational study aims to elucidate the patterns and predictors of intraoperative
lung protective ventilation (LPV) in adult patients undergoing non-cardiac surgery at
Fraser Health Authority, a large Canadian health authority on the west coast of Canada,
between 2014-2023. It also assesses the impact of pre-COVID vs. 2020s era on LPV
compliance, and interactions of predictors with pre-COVID vs. 2020s era. LPV is defined
as both 1) tidal volume of 6-8mL/kg ideal body weight and 2) positive end-expiratory
pressure of 5 cmH2O or more. Intraoperative data will be derived from the intraoperative
anesthesia information management system, and the perioperative data from the regional
electronic medical record. The investigators will use a predictive logistic regression
model to ascertain statistically significant predictors to LPV. Hypothesized predictors
of LPV compliance based on literature and expert opinion will be considered for inclusion
in the model. Pre-COVID and 2020s data will be compared, and interactions with predictors
will be explored. As a secondary analysis, a Shewhart chart will be used to elucidate any
special cause variation in LPV compliance introduced by the COVID pandemic. For details
of descriptive analyses, model derivation, and Shewhart chart methodology, please refer
to study protocol.
Inclusion Criteria:
- over the age of 18
- underwent general anesthesia with endotracheal tube placement for a procedure
lasting ≥30 minutes.
- included in both our clinical anesthesia record database and the National Surgical
Quality Improvement Program (NSQIP) database, and linkable by usual identifiers
(name, date of birth, medical record number, personal health number, date of
surgery)
Exclusion Criteria:
- no endotracheal tube utilized
- cardiothoracic surgery
- organ donation surgery
- organ transplant recipient
- Hyperthermic intraperitoneal chemotherapy
- surgical procedure related to an occurrence or complication of prior procedure
during the same admission/within 30 days,
- multiple NSQIP assessed cases within 30 days only for same patient
- cases in clinical anesthesia record database that are unable to be linked to NSQIP
data or vice versa.
Fraser Health Authority
Surrey, British Columbia, Canada
Perseus Missirlis, MD, MSc, Principal Investigator
University of British Columbia