Our main objective is to analyze the development of physical impact, mental health andblood profile over follow-up time during the 1st wave of the COVID-19. Besides, we aim toestablish a database of post-COVID-19 based on simultaneous cortico-spinal magneticresonance imaging data to identify high-risk patients with long COVID and prevent theneurological symptoms evolution, optimize the tactics of management in China.
This is an observational, cross-sectional, and multicenter study. It will be performed at
9 public hospitals. Participants with confirmed cases of mild or moderate COVID-19
infection will complete the following programs at acute infection phase and after 3, 12
months for exploring biological mechanism and predictive biomarkers of post-COVID-19: 1)
fill in the behavioral psychology scales, 2) submit blood samples at a local laboratory,
3) accept the simultaneous cortico-spinal magnetic resonance imaging scan. The uninfected
healthy controls will complete the same programs as infected group mentioned above only
at the time of inclusion. We will establish the simultaneous cortico-spinal magnetic
resonance imaging database containing neuropsychological scales and blood parameters of
post-COVID-19 in China.
Device: Simultaneous cortico-spinal magnetic resonance imaging, Serum
Simultaneous cortico-spinal magnetic resonance imaging data were collected in a strong
magnetic field and collected the serum of participants.
Inclusion Criteria:
Confirmed diagnosis of mild Covid-19 (WHO criteria)/Confirmed diagnosis of moderate
Covid-19 (WHO criteria)/Healthy people who have not had COVID-19
Exclusion Criteria:
History of central nervous system diseases, such as mental disorder, degenerative
diseases of central nervous system, tumors, trauma, etc. Participants with indication for
MRI studies
First Affiliated Hospital of Xian Jiaotong University
Xi'an, Shaanxi, China
Investigator: Ming Zhang, PhD
Contact: 0086-18991232265
zmmri@163.com
Ming Zhang, PhD
0086-18991232265
zmmri@163.com
Xuan Niu, PhD
0086-13289275082
niuxuan911@163.com
Ming Zhang, PhD, Principal Investigator
First Affiliated Hospital of Xian Jiaotong University