Inclusion Criteria:

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1. Willingness to provide a written ICF before entering the study;

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2. Male or non-pregnant female patients, ≥ 18 years of age at the time of
enrolment (or other age required by local regulations);

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3. Patient with the diagnosis of COVID-19 and with the Ct value <30 in SARS-CoV-2
RT-PCR;

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4. Patients with any comorbidity below at screening:

1. Hematologic cancer;

2. Solid tumor that requires chemotherapy or other systemic therapy;

3. Well controlled autoimmune diseases; or any other medical comorbidities that
requires immunosuppressive therapy;

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5. Non-responder to the treatment of any other anti-SARS-CoV-2 drugs, i.e.,
remdesivir, nirmatrelvir/ritonavir, and/or molnupiravir; or patients who is not
suitable to receive the other anti-SARS-CoV-2 drugs by investigator's judgement
and has Ct <30 14 days after the symptom onset of COVID-19. Non-responder is
defined as a patient who received remdesivir, nirmatrelvir/ritonavir, and/or
molnupiravir but still has Ct <30 14 days after the symptom onset of COVID-19.

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6. Agrees to the collection of nasopharyngeal or pharyngeal swabs and blood sample
as per protocol.

Exclusion Criteria:

-

1. Known history or presence of decompensated cirrhosis of the liver (Child-Pugh B
or C) before study entry;

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2. Chronic kidney disease with eGFR <15 mL/min/1.73 m2;

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3. Females who are breast-feeding, lactating, pregnant or intending to become
pregnant;

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4. Known history of severe allergic or hypersensitivity reactions to the active
substance or to any of the excipients of ropeginterferon alfa-2b;

-

5. Known history or presence of poorly controlled or clinically significant
medical conditions that are not suitable to be enrolled, at the discretion of
the investigator, e.g., major psychiatric (including but not limited to those
with severe depression, severe bipolar disorder, schizophrenia, suicidal
ideation or history of suicidal attempt) or poorly controlled autoimmune
diseases;

-

6. Clinically significant medical conditions known to interfere with absorption,
distribution, metabolism or excretion of the study drugs;

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7. Patients treated by monotherapy of telbivudine or any other combination therapy
with telbivudine within 1 month prior to screening;

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8. Use of an investigational medical product within 1 month prior to screening.