using intermittently scanned continuous glucose monitoring (isCGM) to clarify thecharacteristics of blood glucose variability parameters in T2DM patients with NCP, guidethe formulation of reasonable clinical treatment measures and make timely and reasonableadjustments, improve the prognosis of patients, shorten the length of hospital stay, andreduce medical costs.The goal of this observational study is to investigate the characteristics of bloodglucose variability in patients with type 2 diabetes mellitus (T2DM) complicated withnovel coronavirus pneumonia (NCP) and its effect on disease progression and prognosis.The main question it aims to answer is:After fully lifting coronavirus disease 2019(COVID-19) pandemic control measures in mainland China in 12/2022, the incidence ofCOVID-19 has increased markedly, making it difficult to meet the general time-in-range(TIR) requirement. Therefore, the investigators investigated a more clinically practicalTIR threshold and examined its association with the prognosis of COVID-19 patients withtype-2 diabetes.participant population/health conditions：Participants were equipped with isCGM sensors onadmission.According to the outcome, the patients were divided into favorable outcome group andcomposite outcome group.
patients with NCP who were discharged or died. Clinical data and blood glucose
variability parameters were collected by computer blood glucose monitoring technology
(CGM). Time in range (TIR), time above target range (TAR), time below target range (TBR),
mean amplitude of glycemic excursions (MAGE), absolute mean daily difference (MODD) and
other indicators were used.
Other: Glucose variability
A retrospective cohort study was conducted in hospitalized T2DM patients with NCP who
were discharged or died. Clinical data and blood glucose variability parameters were
collected by computer blood glucose monitoring technology (CGM). Time in range (TIR),
time above target range (TAR), time below target range (TBR), mean amplitude of glycemic
excursions (MAGE), absolute mean daily difference (MODD) and other indicators were used.
Inclusion Criteria:
1. All patients met the diagnostic criteria of type 2 diabetes mellitus in "Chinese
Guidelines for the Prevention and treatment of type 2 Diabetes Mellitus (2020
edition)" formulated by the Chinese Diabetes Society of the Chinese Medical
Association, and were previously diagnosed with type 2 diabetes mellitus and newly
diagnosed with type 2 diabetes mellitus after admission
2. Patients with mild, moderate, severe and critical COVID-19 in accordance with the
guidelines of "Diagnosis and Treatment of novel coronavirus Infection (Trial version
10)"
3. Patients receiving CGM or peripheral blood glucose monitoring during hospitalization
Exclusion Criteria:
1. Cases with incomplete data
2. Non-NCP and non-T2DM patients
3. Patients who did not receive CGM or peripheral blood glucose monitoring
Qilu hospital of shandong university
Jinan, Shandong, China
Investigator: Kuanxiao Tang, M.D.
Contact: 18560082261
tangkx_ql@hotmail.com
Kuanxiao Tang, M.D.
18560082261
tangkx_ql@hotmail.com
Kuanxiao Tang, M.D., Principal Investigator
Qilu Hospital of Shandong University