The purpose of this study is to test if senescent cells and their secretome contribute toLong-Hauler Syndrome and if a clinical trial of senolytic drugs, which selectivelyeliminate senescent cells, should be initiated.
Not Provided
Longhauler's Cohort -
Inclusion Criteria:
- Ability to give informed consent or LAR.
- At least 18 years old.
- Ability of subject or LAR to read and speak the English language.
- Positive PCR or antibody test within 12 months of initial study visit.
- Patient of the Long-Hauler Syndrome clinic and differential diagnosis of Long-Hauler
Syndrome.
Exclusion Criteria:
- Any potential participant who refuses medical record review.
- Pregnant females.
- Incarcerated individuals.
- Inability to cooperate or any medical condition that, in the opinion of the
investigator, interferes with the evaluation of the study objectives or increases
the subject's risk by participating in the study.
Control Cohort -
Inclusion Criteria:
- Ability to give informed consent
- At least 18 years old
- Ability of subject to read and speak the English language
Exclusion Criteria:
- Known case of COVID-19.
- Any potential participant who refuses medical record review.
- Pregnant females.
- Incarcerated individuals.
- Inability to cooperate or any medical condition that interferes with the evaluation
of the study objectives or increases the subject's risk by participating in the
study.
COVID-19 Control Cohort
Inclusion Criteria:
- Ability to give informed consent.
- At least 18 years old.
- Ability of subject to read and speak the English language.
- Known case of COVID-19.
Exclusion Criteria:
- Known Longhauler's syndrome/Post-COVID
- Any potential participant who refuses medical record review.
- Pregnant females.
- Incarcerated individuals.
- Inability to cooperate or any medical condition that interferes with the evaluation
of the study objectives or increases the subject's risk by participating in the
study.
Mayo Clinic in Rochester
Rochester, Minnesota, United States
James Kirkland, MD, PhD, Principal Investigator
Mayo Clinic