In 2022, though the optimized acute medical treatment of COVID-19 was determined,patients often experience the sequelae (also known as post-acute COVID-19 syndrome, thepatients might develop cough, breathlessness, fatigue, weakness, impaired activities ofdaily livings etc.). Until now, there is no consensus for post-acute COVID-19 syndromemanagement. Previously, the cardiopulmonary rehabilitation revealed significant benefitsin heart failure or chronic obstructive pulmonary disease. The aims of the study aredemonstrating the benefits and safety of cardiopulmonary rehabilitations in patientspreviously admitted to hospital because of COVID-19 with sequelae.
PURPOSE: To demonstrate the benefits and safety of cardiopulmonary rehabilitations in
patients previously admitted to hospital because of COVID-19 with sequelae.
METHODS: The participants will be divided into two groups: one with cardiopulmonary
rehabilitations programs under the supervision of therapists 3 times a week, 12 weeks in
total with lifestyle modification (experimental group); and the other with lifestyle
modification and health education (active-controlled group). Before and after the
interventions, several endpoints in interested are performed by the physicians or the
research assistants, including cardiopulmonary exercise training (CPET),
6-minute-walk-test (6MWT), pulmonary function tests (PFT), and quality of life (QoL, we
plan to use SF-36) questionnaire.
Other: Cardiopulmonary rehabilitation
Cardiopulmonary rehabilitation helps patients maximize functional potential due to
progressive deconditioning or acute decompensation following an acute medical event. This
intervention is medically supervised and individualized according to their results of the
cardiopulmonary Exercise Testing (CPET).
Other: Health education
Individualized exercise prescription will be given according to their results of the
cardiopulmonary Exercise Testing (CPET). Recommendations for lifestyle modification will
also be given.
Inclusion Criteria:
- be willing and able to provide written informed consent and comply with all
procedures required by the protocol
- be 20 - 80 years of age at the time of signing the Informed Consent Form
- diagnosed with COVID-19 with PCR and admitted with at least moderate COVID-19
disease (with clinical symptoms or imaging evidence of low respiratory tract
involvement)
- diagnosed with COVID-19 for over 4 weeks but less than 2 years with fatigue,
shortness of breath, cough, weakness, or impairments of activities of daily life
- able to cooperate with the rehabilitation programs and cycling
Exclusion Criteria:
- Patients under 20-year-old or over 80-year-old, pregnant, prisoners
- Patients without national health insurance in Taiwan
- The patient cannot follow instructions or cycling
Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare
Taipei, Taiwan
Investigator: Mei-Sean Loh
Contact: +886 02-22490088
19210@s.tmu.edu.tw
Hung-Chou Chen, MD
+886 02-22490088 - 1630
10462@s.tmu.edu.tw
Not Provided