Preliminary studies suggest that COVID-19 causes long-term lung damage, even in young,otherwise healthy people who did not need to go to hospital or the ICU.We seek to know how common long-term lung damage after COVID-19 is, who is most affectedby it and what the effects of this damage are on other important aspects of people'slives. We plan to study a large sample of people with a history of COVID-19 infectionfrom across Canada-some who needed hospitalization but most who did not. Through onlinequestionnaires, we will determine their respiratory symptoms, quality of life and medicalhistory. Then we will invite them to one of our thirteen Canadian testing centres to havespecial, thorough breathing tests.We hypothesize that COVID-19 leaves a significant proportion of people with measurablerespiratory impairment.The information we learn about the effect of COVID-19 on the lungs will help patients andhealth care providers manage it better. It will also reveal how different COVID-19variants affect the lungs. We will use this new knowledge to write a formal guide on whatrespiratory monitoring and testing should be done after COVID-19 infection. This willensure that people affected by COVID-19 get the care they need to maintain their lunghealth.
We will prospectively recruit a representative, random sample of adult (age ≥ 18),
community-dwelling patients, who have had a positive PCR test for COVID-19 infection and
symptomatic infection five to 12 months previously.
This cross-sectional, observational study will have two phases:
1. Screening:
Screening for eligibility
2. Observation Period:
1. Online / telephone visit: All participants will complete a series of
questionnaires (either online or by phone with the assistance of research
personnel). In the questionnaires they will be asked about respiratory symptoms
(the primary outcome), baseline participant data, burden of respiratory
symptoms, overall quality of life, mental health issues as well as physical and
psychological trauma from COVID-19.
2. In-person visit: All participants will complete pulmonary function testing
including oscillometry.
The study of COVID-19 infection and its long-term effects is constantly evolving. Over
the course of this research study, new knowledge may become available that may lead to
changes in the study's outcome measures.
Inclusion Criteria:
- Aged ≥18
- Community dwelling
- First occurrence of a positive diagnostic test for SARS-CoV-2 infection (i.e., PCR
or rapid antigen test, including at-home rapid antigen test) and symptomatic
infection 5-12 months previously
- Consent provided
- Willing and able to go to study site for pulmonary function testing including
oscillometry
Exclusion Criteria:
- Not able to communicate with our research personnel (themselves or through a
translator)
St. Paul's Hospital
Vancouver, British Columbia, Canada
Queen Elizabeth II Health Sciences Centre
Halifax, Nova Scotia, Canada
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada
Kingston Health Sciences Centre
Kingston, Ontario, Canada
The Ottawa Hospital
Ottawa, Ontario, Canada
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
St. Michael's Hospital
Toronto, Ontario, Canada
Institut Universitaire de Cardiologie et de Pneumologie de Québec
Québec, Canada
Andrea Gershon, MD, MSc, Principal Investigator
Sunnybrook Health Sciences Centre