This observational prospective study is aimed to investigate noncoding RNAs (ncRNAs) suchas microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) as potential peripheral bloodbiomarkers of severity and poor prognosis in COVID-19 patients. Patients withintermittent or permanent symptoms after COVID-19 at the moment of the recruitment wereconsidered affected by LONG COVID disease. In particular, the aim is to clarify ifCOVID-19 biomarkers remain deregulated similarly in LONG COVID patients. To this purpose,plasma and peripheral blood mononuclear cells (PBMCs) will be collected and patients willbe compared to individuals who have never been affected by COVID-19 or asymptomatic LONGCOVID patients.
The investigators will collect plasma and PBMCs from consenting subjects. The
investigators will evaluate the expression of miRNAs, lncRNAs and cytokines in patients
affected by LONG COVID admitted to IRCCS Policlinico San Donato during the acute phase of
COVID-19. In particular, miRNAs will be evaluated in plasma samples while lncRNAs in PBMC
samples to clarify their potential as biomarkers.
Diagnostic Test: Measurement of ncRNAs and cytokines
Measurement of lncRNAs in PBMCs samples and miRNAs in plasma samples.
Inclusion Criteria:
- Previous COVID-19 infection
Exclusion Criteria:
-
Irccs Policlinico San Donato
San Donato Milanese, Milan, Italy
Investigator: FABIO MARTELLI, PhD
Contact: 0252774683
fabio.martelli@grupposandonato.it
Fabio Martelli, Dr
+39 0226437762
fabio.martelli@grupposandonato.it
Not Provided