In the context of the actual pandemia of the Severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2) which requires a better diagnostic strategy for the managementof patients.The study of volatile organic compounds (VOC) detected in exhaled air or in sweat, is aninnovative research area for respiratory diseases. The analysis of VOC can be done eitherby the technique of the mass spectrometry which allows the identification of each VOC inthe exhaled air or by the technique of electronic nose, simpler and faster, whichprovides an idea of the general profile of the VOC without identifying them. The VOC haveshown their interest in some situations, such as diagnostic or prognostic tool inpatients followed for thoracic tumorous pathology or bronchial or pulmonary vasculardiseases.Moreover, it has recently been shown that properly trained dogs would be able to detectan olfactory signature of SARS-CoV-2 infection with a specificity greater than 90%; thisolfactory signature corresponds to VOCs detectable by the flair of dogs (Nosaïs-Covid19study).Validation of the diagnostic value of VOC analyzes by non-invasive and rapid methods(electronic nose analysis or mass spectrometry; detection by the scent of dogs) for therapid detection and early diagnosis of a SARS-CoV-2 infection warrants the performance ofthis clinical study.
Not Provided
Device: Volatile Organic Compounds analysis (e-noses)
VOC analysis in exhaled air with e-noses.
Other: Canine odor detection of Volatile Organic Compounds
VOC analysis in sweat by trained dogs.
Device: Volatile Organic Compounds analysis (mass spectrometry)
VOC analysis in exhaled air with mass spectrometry.
Device: Volatile Organic Compounds analysis in sweat (mass spectrometry)
VOC analysis in sweat with mass spectrometry.
Inclusion Criteria:
- Subject included in the Foch Hospital :
- Patients managed at the Foch Hospital with RT-PCR screening for SARS-CoV-2 infection
- Healthy volunteers among the hospital staff, asymptomatic, for whom an RT-PCR
SARS-CoV-2 is indicated or recommended.
- Healthy hospital volunteers vaccinated against COVID (full vaccination schedule
completed)
- At least 18 years of age;
- Fluency in the French language;
- Have signed a consent form;
- Be affiliated with a health insurance plan.
Exclusion Criteria:
- Pregnant woman
- Patient deprived of liberty by judicial or administrative decision
Foch hospital
Suresnes, France
Investigator: Philippe Devillier, PhD
Contact: 0146252791
p.devillier@hopital-foch.com
Philippe Devillier, PhD
0146252791 - +33
p.devillier@hopital-foch.com
Elisabeth Hulier-Ammar, PhD
0146251175
drci-promotion@hopital-foch.com
Philippe Devillier, PhD, Principal Investigator
Hopital Foch