The course of coronavirus infection was often severe and required hospitalization ofpatients in the intensive care unit. The new SARS-Cov-2 has been poor studied, sorelatively reliable markers are needed to effectively monitor patients and predictcomplications and outcome. Taking into account the known mechanisms of pathogenesis, thebiochemical markers as ferritin, procalcitonin, C-reactive protein and D-dimer werechosen for this purpose. Patients were divided according to the degree of pulmonaryinfiltration. We hypothesized that the markers would correlate with dynamics,complications, and outcomes.
In the presented study, an analysis of the medical records of 193 patients hospitalized
in severe condition to the intensive care unit with a confirmed diagnosis of Coronavirus
infection COVID-19 was carried out. Taking into account the volume of pulmonary
infiltration according to computer tomography (CT) of the chest organs, patients were
divided into 4 groups in accordance with the approved classification: CT 1(up to 25% of
lung tissue was infiltrated) - 27 patients, CT 2 (25-50%) - 60 patients, CT 3 (50-75%) -
67 patients, CT 4 (75% and more) - 39 patients. The following biochemical parameters were
selected and used to monitor dynamics: procalcitonin (PCT), C-reactive protein (CRP),
D-dimer (DD), ferritin (FRT). The duration of observation was 15 days.
In order to determine correlations between quantitative and qualitative data at different
stages of treatment, a correlation analysis was carried out (Spearman's test was used).
ROC analysis was performed to evaluate selected laboratory markers as predictors of
outcome. Next, the odds ratio (OR) was assessed taking into account the obtained Youden's
J index and the Associated criterion for each of the selected markers in relation to the
patient's outcome. Preliminary contingency tables were compiled in relation to laboratory
parameters and outcomes (2x2 tables).
Data were processed using statistical software jamovi (Computer Software ,Version
2.3.26), MedCalc (MedCalc Software Ltd, Ostend, Belgium), Microsoft Office Excel, 2016.
Diagnostic Test: CT of the chest organs, blood biochemical parameters
Taking into account the clinical manifestations, all patients underwent chest computed
tomography (CT) to diagnose COVID-19-associated pneumonia. According to the CT results,
all patients were classified into one of 4 subgroups, according to the degree of
pulmonary infiltration. The following biochemical parameters were selected and used to
monitor dynamics: procalcitonin (PCT), C-reactive protein (CRP), D-dimer (DD), ferritin
(FRT). Biochemical markers were determined daily during the stay in the intensive care
unit. The duration of observation was 15 days was selected. Information was analysed
retrospectively.
Inclusion Criteria:
- identified COVID-19 by nasopharyngeal material PCR, coronavirus associated lung
infiltration, visualized by CT, and clinically severe condition
Exclusion Criteria:
- pregnancy
Karaganda Medical University
Karaganda 609655, Kazakhstan
Aissulu Issabekova, MD, Study Chair
Karaganda Medical University