The subject of the project is the impact of COVID-19 on the exercise capacity ofpatients. The long-term sequelae of COVID-19 infection are still unknown. It is not yetclear whether pulmonary sequelae, which may be a consequence of the disease, areassociated with a measurable functional deficit. In this project, the aerobic capacity ofhealthy people will be compared with individuals who have experienced Covid-19, and theamount of increase in aerobic capacity will be determined at the end of 15 sessions byapplying a rehabilitation program including bicycle ergometry to individuals who haveexperienced Covid-19 Detailed description : In December 2020, in the pneumonia epidemicin which the city of Wuhan, China is the center, pneumonia developed due to the newlydefined SARS-CoV-2 factor was defined as Coronavirus disease 2019 (COVID-19). It has beenobserved that clinical findings of SARS-CoV-2 infection in patients hospitalized in Wuhanrange from mild manifestations such as asymptomatic disease and mild upper respiratorytract infection to severe viral pneumonia accompanied by respiratory failure and mayresult in death.The long-term sequelae of COVID19 are still unknown. Pulmonary sequelaethat impair physical fitness have been predominantly defined for hospitalized patientswith COVID-19. Although lung lesions have been identified as asymptomatically in infectedindividuals, it is not yet clear whether these observations are related to a measurablefunctional deficit in physical fitness. They measured the change in the predicted maximumaerobic capacity (VO2 max) of non-infected,asymptomatically infected, and recoveringCOVID-19 individuals with a well-established and validated physical fitness test beforeand after the COVID-19 outbreak among young Swiss adults.They demonstrated decreasedaerobic capacity in young adults 1 to 2 months after symptomatic COVID-19 withoutphysical strength being affected. In their study, 19% of young adults who recovered afterCOVID-19 had a VO2 max decrease of more than 10% compared to baseline before infection.It has been identified that decreased VO2 max value is the hallmark of interstitial lungdisease. SARS-CoV-2 infection causes lung damage even in asymptomatic cases.A total of 64 people, including 32 people in 2 groups between the ages of 18-55, who haveor have not had corona virus infection, who applied to Bülent Ecevit University Facultyof Medicine Physical Therapy and Rehabilitation or Infectious Diseases outpatient clinicsfor different reasons, will be included in our project. The research start date isFebruary 2021 and the end date is February 2023. At the beginning of the study,demographic information of the individuals such as gender, age,height, weight,occupation, education, body mass index, physical activity level (international physicalactivity index-IPAQ), the most used hand (dominant hand) in daily life activities will berecorded. In the control group, resting heart rate, blood pressure, saturationmeasurement, ECG will be performed before exercise. In addition, in order to evaluatetheir muscle strength, microFET3 manual muscle measurement device will be used to measurethe triceps muscle strength in the upper extremity they actively use, and the quadricepsmuscle strength of the same side will be measured, and their grip strength will bemeasured with the JAMAR hydraulic hand dynamometer. Using the international physicalactivity index(IPAQ), activity status in daily life will be assessed. The exercisecapacity of all individuals will be measured with the aid of the COSMED Quark CPET deviceusing the bicycle ergometry test recommended by the American Society of Cardiovascularand Pulmonary Rehabilitation. In this test, submaximal exercise test will be performed byproviding 25 W increase in 2 minutes periods after the warm-up period at 0 load (W) for 2minutes. In addition, the borg scale obtained at the end of the test, metabolicequivalent of task (MET) and maximum work (W), test duration, maximum heart rateparameters will also be recorded in order to evaluate the exercise capacity.Individuals who have been confirmed by the previous SARS-COV 2 real-time reversetranscriptase polymerase chain reaction (RT-PCR) test to have coronovirus infection afterthe test will be included in a treatment program of 15 sessions, at least 3 sessions perweek, with bicycle ergometry. After 15 sessions, exercise capacity will be re-evaluatedusing the cycling test, the aforementioned triceps and grip muscle strengths, V02 max,maximum conjugate (MET), maximum work (w), borg scale, maximum heart rate, test timeparameters will be saved again after treatment.
The cardiopulmonary exercise test was also performed on 14 individuals from the control
group and 15 individuals in the patient group, and by this test, the respiratory exchange
ratio (RER), anaerobic threshold (AT), maximum oxygen capacity (VO 2peak ), maximum
ventilatory capacity at anaerobic threshold (VO 2AT ), carbon dioxide ventilatory
equivalent (VE/CO 2 ), heart rate recovery (HRR) and heart rate recovery at 1 min (HRR1)
parameters were evaluated. The test was repeated after 15 sessions of aerobic exercise
training for the individuals in the COVID-19 group who participated in the
cardiopulmonary exercise test, and the patients were evaluated using the same parameters.
Device: Kardiopulmonary exercise test (Quark KPET C12x/T12x device connected to the Omnia version 1.6.8 COSMED system)
For the cardiopulmonary exercise test, a Quark KPET C12x/T12x device connected to the
Omnia version 1.6.8 COSMED system, supported by analyzers that measure oxygen uptake and
carbon dioxide output, and a bicycle ergometer connected to the ergoline rehab system 2
Version 1.08 SPI system were used. At the end of the test, the individual's RER , VAT,
VO2peak, VO2AT, VE/CO2, HRR, HRR1 values were recorded. These values were estimated by
the device based on the "wasserman extended" protocol on the Quark KPET C12x/T12x device
connected to the Omnia version 1.6.8 COSMED system.The test was repeated after 15
sessions of aerobic exercise training in the Covid-19 group.This intervention was applied
to 14 people in the COVID-19 group and 15 people in the control group. It was repeated at
the end of 15 sessions of aerobic exercise training in the COVID-19 group.
Device: Peripheral muscle strength measurement (microFET3 (Hoggan Health Industries, Fabrication Enterprises, lnc) and JAMAR hydraulic hand dynamometer (Sammons Preston, Rolyon, Bolingbrook).
Quadriceps and triceps muscle strength was measured in kilograms using the microFET3
(Hoggan Health Industries, Fabrication Enterprises, lnc) manual muscle strength
measurement device in the lower and upper extremity. Hand grip strength was evaluated in
the dominant upper extremity using a JAMAR hydraulic hand dynamometer (Sammons Preston,
Rolyon, Bolingbrook)This intervention was repeated for individuals in both groups at the
beginning and at the end of the 15-session aerobic exercise training planned for the
COVID-19 group.
Device: Standard exercise tolerance test (a bicycle ergometer and recorded through the ergoline rehabilitation system 2 Version 1.08 SPI.)
At the beginning of this test, resting pulse and blood pressure were measured and
recorded. The test was performed following a bicycle ergometer protocol recommended by
the American Cardiovascular and Pulmonary Rehabilitation Society. After a 2-minute
warm-up period at 0 load (W), a submaximal exercise test was performed by increasing the
load by 25 W in 2-minute periods. At the end of the test, exercise intensity was
evaluated with the perceived difficulty level (borg scale), test duration, maximum heart
rate, maximum work (W). , metabolic equivalent (MET) values were recorded. VO2peak and
VO2peakpredictive levels were calculated. This test was repeated for individuals in both
groups at the beginning and at the end of the 15-session aerobic exercise training
planned for the COVID-19 group.
Device: Aerobic exercise training (a bicycle ergometer and recorded through the ergoline rehabilitation system 2 Version 1.08 SPI.)
Aerobic exercise training was planned for the COVID-19 group with the help of a bicycle
ergometer and recorded through the ergoline rehabilitation system 2 Version 1.08 SPI.
Aerobic exercise training was applied for a total of 15 sessions, at least 3 days a week,
under the supervision of a physician.
Inclusion Criteria:
- Being a healthy volunteer between the ages of 18-55
- be an independent ambulance
Exclusion Criteria:
- -Not being willing to participate in the study
- Be over 55 years old
- Previous symptomatic or asymptomatic coronavirus infection
- Severe audio-visual loss Unstable cardiovascular, neurological or psychiatric
disease
- Pregnancy status
- Active asthma and exacerbation of COPD
- Malignancy Neurodegenerative disease with muscle destruction
Zonguldak Bülent Ecevit University
Zonguldak 737022, Turkey (Türkiye)
Not Provided