In this study, a 12-week pragmatic, randomized, double-blinded clinical trial will beconducted to evaluate the efficacy of acupuncture for the treatment of long Covidneuropsychiatric symptoms and provide reference for clinical non-drug treatment.
This is a pragmatic, randomized, double-blinded clinical trial on acupuncture for
treating neuropsychiatric symptoms in long Covid patients. A total of 160 participants
will be diagnosed by a registered Chinese medicine practitioner and randomly assigned to
the acupuncture and the control group with a 1:1 ratio. The acupuncture group will
receive 24 sessions of interventions during a 12-week treatment duration (2 sessions per
week) and will be followed up at week 18. The control group will only receive
conventional therapy.
Device: Acupuncture
1. Fatigue Principal points: Pishu (BL 20), Ganshu (BL 18), Shenshu (BL 23), Baihui (GV
20), Guanyuan (RN 4), Zusanli (ST 36), Sanyinjiao (SP 6)
2. Anxiety/ depression Principal points: Yintang (EX-HN3), Baihui (GV 20), Taichong (LR
3), Neiguan (PC 6), Danzhong (RN 7)
3. Cognitive impairment/ memory loss Principal points: Baihui (GV 20), Sishencong
(EX-HN1), Fengfu (GV 16), Taixi (K 13), Xuanzhong (GB 39), Zusanli (ST 36)
4. Insomnia Principal points: Zhaohai (K 16), Shenmai (BL 62), Shenmen (HT 7),
Sanyinjiao (SP 6), Anmian (EX-HN22), Sishencong (EX-HN1)
Inclusion Criteria:
- meet the clinical diagnosis of Long COVID by the World Health Organization (WHO),
with no neuropsychiatric symptoms 1 year before infection with Covid-19, and
continue to have at least one neuropsychiatric symptom for 2 months after SARS-CoV-2
turned negative 3 months above;
- aged 12 to 80 years;
- willing and able to consent, and complete all assessment and study procedures
Exclusion Criteria:
- patients with a history of chronic neuropsychiatric symptoms;
- cardiovascular diseases pre-existing to the Covid-19 episode such as arrhythmia,
heart failure, myocardial infarction, and patients with cardiac pacemakers;
- documented pre-existing history of psychiatric illness, including substance abuse;
- suicidal tendencies (attempted suicide in the 12 months before the study);
- any chronic or remote neurological disorder (i.e. stroke, head trauma, epilepsy,
tumor);
- those who participated in other clinical trials within one month;
- pregnant or lactating female patients;
- have surgery within two months before the study or will have a scheduled surgery
during the study;
- acute brain injury or acute encephalopathy from another etiology than Covid-19
(e.g., sepsis, liver or renal failure, alcohol or drug withdrawal, drug toxicity);
- open-heart cardiac surgery or cardiac arrest during the last 6 months;
- patients who received acupuncture treatment 1 month before the start of the study;
- patients who were unable to complete the assessment during screening due to severe
mental, cognitive, or emotional impairment
Linda Zhong
Kowloon Tong, Kowloon, Hong Kong
Investigator: Linda Zhong, MD,PhD
Contact: 34116523
ldzhong0305@gmail.com
Linda Zhong, MD., Ph.D
85234116523
ldzhong0305@gmail.com
Dong Jue Wei, MD., Study Chair
Hong Kong Baptist University